Testing self-adjusting breathing machine settings in people with lung and sleep apnea disease
Compares fixed and self-adjusting airway pressure machines in people with COPD and sleep apnea.
Plain-language title generated from the registry record
Registry title: Efficacy of Self-titration of Ventilation in Overlap Syndrome (chronic Obstructive Pulmonar Disease + Sleep Apnea Syndrome ) with Dynamic Hyperinflation. EDIN-IDIN.
Key facts
- Where
- Murcia, SpainSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 50 to 80 with COPD and sleep apnea together, stable for at least 4 weeks, who previously had a high carbon dioxide level (PCO2 above 52).
- Age
- 50 to 80 years
- Sex
- Men and women can join.
- Disease stage
- COPD together with sleep apnea (overlap syndrome) with dynamic hyperinflation. Stable for at least 4 weeks without a hospital stay.
- Biomarker or test result
- Previously had a PCO2 above 52.
Main reasons for not taking part
- Uncontrolled heart disease
- LVEF below 45%
- Central sleep apnea (50% or more central events)
- Uncontrolled pulmonary hypertension
- Flare-up of COPD in the 4 weeks before
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 80 years old?
Source: NCT06713486, who can take part
Where in Spain
- Servicio de Neumología. Hospital Universitario Virgen de la Arrixaca.Murcia, SpainContact: Francisco José Ruiz López Ruiz Lopez, MDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
- Trial code
- NCT06713486
- Record updated
- 3 December 2024
- Original description
The combination of COPD and obstructive sleep apnea (OSA) can lead to undesirable interactions with the treatment approach. The investigators know that continuous positive airway pressure (CPAP) can increase dynamic hyperinflation in COPD patients, and in mechanical ventilation, the increase in PEEP can worsen dynamic hyperinflation. On the other hand, the team know that the severity of COPD obstruction and hyperinflation alter sleep efficiency, with periods of wakefulness during sleep, and during these periods, the patient would not have upper airway obstruction, which could affect the therapy they are receiving in CPAP mode for OSA. Moreover, it was observed that with greater hyperinflation, the rate of obstructive events decreases, dynamically affecting the ventilatory situation with upper airway resistance. Recent studies have determined the safety and efficacy of auto-adjusting systems in the treatment of overlap syndrome, which could be more adaptable to the changing pulmonary mechanics of these patients. Aerobic capacity is a good predictor to the health status in these patients and the investigators know it is reduced in patients with AOS, where CPAP treatment according to studies improves the peak VO2. Therefore, the objective is to compare a ventilation system with fixed pressures established through polysomnography in patients with overlap syndrome and dynamic hyperinflation to a dynamic ventilation system using the fixed pressure limits typically established, based on their impact on the aerobic capacity (peak VO2) of these patients after 1 month of treatment.Read full original descriptionShow less
Efficacy of Self-titration of Ventilation in Overlap Syndrome (chronic Obstructive Pulmonar Disease + Sleep Apnea Syndrome ) with Dynamic Hyperinflation. EDIN-IDIN.
The combination of COPD and obstructive sleep apnea (OSA) can lead to undesirable interactions with the treatment approach. The investigators know that continuous positive airway pressure (CPAP) can increase dynamic hyperinflation in COPD patients, and in mechanical ventilation, the increase in PEEP can worsen dynamic hyperinflation. On the other hand, the team know that the severity of COPD obstruction and hyperinflation alter sleep efficiency, with periods of wakefulness during sleep, and during these periods, the patient would not have upper airway obstruction, which could affect the therapy they are receiving in CPAP mode for OSA. Moreover, it was observed that with greater hyperinflation, the rate of obstructive events decreases, dynamically affecting the ventilatory situation with upper airway resistance. Recent studies have determined the safety and efficacy of auto-adjusting systems in the treatment of overlap syndrome, which could be more adaptable to the changing pulmonary mechanics of these patients. Aerobic capacity is a good predictor to the health status in these patients and the investigators know it is reduced in patients with AOS, where CPAP treatment according to studies improves the peak VO2. Therefore, the objective is to compare a ventilation system with fixed pressures established through polysomnography in patients with overlap syndrome and dynamic hyperinflation to a dynamic ventilation system using the fixed pressure limits typically established, based on their impact on the aerobic capacity (peak VO2) of these patients after 1 month of treatment.
Inclusion: Stability of at least 4 weeks without hospital admission; Previously presented PCO2 > 52; Age between 50 and 80 years; Agree to participate in the study and sign the informed consent; Both sexes.
Exclusion: Having had an exacerbation 4 weeks prior; Uncontrolled structural or coronary heart disease (no changes in medication in the last 15 days); Central sleep apnea syndrome (≥ 50% central events); Uncontrolled pulmonary hypertension; Severe psychiatric illness; Cognitive impairment; LVEF < 45%; Refusal to participate in the study; Inability to perform the tests; Not speaking Spanish; Illiteracy; Active smoker (or < 6 months since quitting smoking).