Studies how oestrogen affects lungs in asthma and COPD
Observes oestrogen's role in lung disease in adults with asthma or COPD.
Plain-language title generated from the registry record
Registry title: InvEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease
Key facts
- Where
- London, United KingdomSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 99 years old?
Source: NCT06713512, who can take part
Where in United Kingdom
- Guys St Thomas NHS Foundation TrustLondon, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Guy's and St Thomas' NHS Foundation Trust
- Trial code
- NCT06713512
- Record updated
- 3 December 2024
- Original description
This study aims to understand the role of oestrogen in patients with asthma and Chronic Obstructive Pulmonary Disorder (COPD). Therefore, what is the effect of oestrogen in these participants compared to controls (those without disease). The study hypothesises that oestrogen loss in patients with asthma and COPD causes accelerated lung function decline and changes to lung structure. It will investigate if this is mediated by inflammation, immune host response or elastin and collagen changes. It is an observational prospective cohort study aiming to recruit healthy controls, and people with asthma or COPD), and/or the menopause.Read full original descriptionShow less
invEstigating oeStrogen Signalling and the Effect upoN the exTracelluar Matrix In pAtients With Obstructive Lung Disease
This study aims to understand the role of oestrogen in patients with asthma and Chronic Obstructive Pulmonary Disorder (COPD). Therefore, what is the effect of oestrogen in these participants compared to controls (those without disease). The study hypothesises that oestrogen loss in patients with asthma and COPD causes accelerated lung function decline and changes to lung structure. It will investigate if this is mediated by inflammation, immune host response or elastin and collagen changes. It is an observational prospective cohort study aiming to recruit healthy controls, and people with asthma or COPD), and/or the menopause.
Inclusion: Men and women aged \> 18 years; For female participants: pre-menopausal, peri-menopausal and post-menopausal women can all be included; Participants willing and able to give informed consent for participation in the study; Healthy controls \<10 pack year history (participants without Asthma or COPD).
Exclusion: Alcohol or recreational drug abuse, is defined as when the use is harmful as per NHS definition; Known or suspected current pulmonary tuberculosis, HIV (human immunodeficiency virus), Hepatitis B Virus, Hepatitis C Virus; History of psychiatric, medical, or surgical disorders; History of advanced medical conditions with an expected prognosis of \< 3 years; Patients with a history of active cancer; Pregnant; Unable to provide written informed consent; Patients on long term oxygen (ambulatory oxygen).