Tests supervised aerobic exercise for women with migraine
Tests supervised exercise and pain education in women aged 18 to 48 with migraine.
Plain-language title generated from the registry record
Registry title: Aerobic Exercise and Its Impact on Sensory, Musculoskeletal, and Psychosocial Aspects in Migraine
Key facts
- Where
- Ribeirão Preto, BrazilSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 48 years old?
Source: NCT06716489, who can take part
Where in Brazil
- Ribeirão Preto Medical School - University of São Paulo (FMRP-USP)Ribeirão Preto, BrazilTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Sao Paulo
- Trial code
- NCT06716489
- Record updated
- 28 April 2026
- Original description
Migraine is a neurological disorder associated with high levels of disability and changes in sensory processing, musculoskeletal function, and psychosocial factors. Aerobic exercise is a low-cost, non-pharmacological strategy that has shown potential benefits for migraine management, but its effects on sensory perception and musculoskeletal function are not yet fully understood.Read full original descriptionShow less
Influence of Aerobic Exercise on Sensory Perception, Musculoskeletal and Psychosocial Alterations in Patients With Migraine
Migraine is a neurological disorder associated with high levels of disability and changes in sensory processing, musculoskeletal function, and psychosocial factors. Aerobic exercise is a low-cost, non-pharmacological strategy that has shown potential benefits for migraine management, but its effects on sensory perception and musculoskeletal function are not yet fully understood.
This randomized controlled trial will investigate the effects of a supervised aerobic exercise program combined with pain neuroscience education compared with an active control condition in women aged 18 to 48 years diagnosed with migraine. Participants will be randomly allocated to either an intervention group, which will perform supervised aerobic exercise three times per week for 16 weeks and receive one session of pain neuroscience education, or a control group, which will receive recommendations for unsupervised physical activity at home.
Outcomes related to migraine-related disability, self-reported symptoms, sensory sensitivity, and musculoskeletal function will be assessed at baseline and after the intervention period. Questionnaires will also be collected at a 6-month follow-up. The results of this study may contribute to the development of accessible and low-risk non-pharmacological treatment strategies for people with migraine.
Inclusion: Women aged between 18 and 48 years; Diagnosed with migraine by an experienced neurologist specialized in headaches, following the criteria of the International Classification of Headache Disorders (ICHD); Frequency of headache between 3 and 8 days per month, to ensure adherence to the treatment.
Exclusion: Presence of any other type of concurrent headache; Abuse of abortive medications; Medical conditions affecting sensitivity and autonomic modulation, such as peripheral neuropathies, autonomic disorders, severe neurological diseases, and others; Conditions that prevent physical activity, such as severe musculoskeletal injuries, cardiovascular diseases, or related conditions; Premature ovarian failure; Smokers or individuals using drugs that interfere with sensitivity and cardiac modulation (e.g., beta-blockers); Regular physical exercise in the past year; Body Mass Index (BMI) above 30.0.