Tracking leg muscle changes after brain injury or stroke over time
Tracks leg muscle stiffness and structure in adults after a brain injury.
Plain-language title generated from the registry record
Registry title: Natural Evolution of Muscle Structure and Stiffness Following Brain Lesion
Key facts
- Where
- Brussels, BelgiumSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06718608, who can take part
Where in Belgium
- Cliniques universitaires Saint-LucBrussels, BelgiumNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Trial code
- NCT06718608
- Record updated
- 5 December 2024
- Original description
We propose to carry out a single center, prospective, interventional trial to assess the natural evolution of lower limb muscle structure and muscle stiffness of hemiparetic patients following brain damage. Patients will be assessed two weeks, one month, three months and six months after their brain lesion.Read full original descriptionShow less
Natural Evolution of Muscle Structure and Stiffness Following Brain Lesion
We propose to carry out a single center, prospective, interventional trial to assess the natural evolution of lower limb muscle structure and muscle stiffness of hemiparetic patients following brain damage. Patients will be assessed two weeks, one month, three months and six months after their brain lesion.
Secondary objectives:
To compare the muscle stiffness and structure of patients who will develop muscle overactivity to patients who won't develop muscle overactivity.
To compare the muscle structure and muscle stiffness of the spastic lower limb muscles and the non-spastic lower limb muscles in the affected limb.
To compare the muscle structure and muscle stiffness of the affected and the non-affected lower limb.
To study the relationship between impairment and function by applying a comprehensive and original method to assess all aspects from muscle structure and mechanics to patient's functional capacities.
Inclusion: Female or male ≥ 18 years and ≤ 80 years at screening; Hemiparesis secondary to a first stroke or traumatic brain injury; < 1 month post-stroke/brain injury Subjects must meet all of the inclusion criteria in order to be eligible to participate in the study.
Exclusion: Underlying neuromuscular disease (e.g. myasthenia gravis, Lambert-Eaton syndrome, amyotrophic lateral sclerosis); Bilateral limb paresis; Major cognitive impairments limiting the functional evaluation; Neurological or orthopedic affection interfering with the paretic limbs function; Contraindication to perform MRI Subjects meeting any of the exclusion criteria at baseline will be excluded from study participation.