Testing a support program to help stroke patients use CPAP for sleep apnea
Tests extra CPAP support for stroke patients with sleep apnea during rehabilitation.
Plain-language title generated from the registry record
Registry title: Stroke and CPAP Outcome Study 3 Randomized Controlled Trial
Key facts
- Where
- Downey and Seattle, United StatesSee the 2 sites
Where in United States
- Rancho Research InstituteDowney, United StatesTaking people
- University of Washington - Harborview Medical CenterSeattle, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Washington
- Trial code
- NCT06722755
- Record updated
- 13 August 2026
- Original description
The SCOUTS 3 study aims to test the effectiveness of an intensive CPAP (Continuous Positive Airway Pressure) therapy support program compared to usual care in stroke patients with obstructive sleep apnea (OSA) during inpatient rehabilitation (IPR).Read full original descriptionShow less
Optimizing Adherence to the Treatment of Sleep Apnea Among Patients With Stroke Undergoing Inpatient Rehabilitation
The SCOUTS 3 study aims to test the effectiveness of an intensive CPAP (Continuous Positive Airway Pressure) therapy support program compared to usual care in stroke patients with obstructive sleep apnea (OSA) during inpatient rehabilitation (IPR).
The study is a multicenter randomized controlled trial (RCT) involving recruitment of about 250 participants across two institutions and randomization of about 200 participants. It compares an intensive support (IS) program for CPAP use with standard support (SS) to evaluate the effectiveness of the IS intervention in increasing CPAP usage during and after stroke rehabilitation. The Intensive Support (IS) group will receive a multicomponent intensive behavioral adherence program, which includes a CPAP technical support intervention, Motivational Enhancement Therapy (MET), and a Mobile Health intervention. Outcomes measured include CPAP adherence as measured by average nightly use in minutes between randomization and 3 months and the modified Rankin Scale (mRS-9Q) to evaluate stroke recovery.
Inclusion: Age 18 years or older; Head CT or brain MRI demonstrating an acute ischemic infarction or intraparenchymal hemorrhage within past 30 days; Person providing consent (patient or legally authorized representative (LAR)) able to be consented in English or Spanish.
Exclusion: Use of positive airway pressure within 14 days prior to stroke; Active use of sedative drugs that can interfere with testing for obstructive sleep apnea (OSA) including any benzodiazepine, barbiturate, general anesthesia, or conscious sedation within the prior 48 hours of the planned portable sleep apnea study; Recent cranial or spinal surgery with known or possible CSF leak or pneumocephalus within past 3 months; History of pneumothorax, bullous emphysema or other serious co-morbid conditions which limit CPAP use; Stroke related to tumors, vascular malformations or subarachnoid hemorrhage; Co-morbid conditions that limit OSA testing or CPAP use in the judgement of the study team; Unable to obtain informed consent from participant or LAR in English or Spanish; Incarcerated; Known pregnancy-determined by reviewing clinical data; Current mechanical ventilation, tracheostomy, or supplemental oxygen use > 4L/min; Anticipated inpatient rehabilitation length of stay < 5 nights; Patients at significant risk of aspiration that could render the patient at risk of harm from use of CPAP, in the opinion of the site PI.