Taking peopleNo phase

Studying how keratoconus differs between children and adults in China

Observes corneal cells to understand keratoconus in children compared with adults.

Key facts

Who runs it: Zhongshan Ophthalmic Center, Sun Yat-sen University
Where: China1 site in 1 countryChoose a country to see its sites
Trial code: NCT06722937
Registry title: The Collagen Factors of Rapid Progression of Keratoconus in Children.
Status: Recruiting
People taking part: 160 people, planned
Started: 14 Apr 2023
Planned end: 13 Apr 2025
Type of study: Observational, 4 groups
Treatments tested: Observation
Record updated: 9 December 2024

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for children and adults with keratoconus, a thinning and bulging of the clear front of the eye (cornea). It also has control groups of children and adults.

Age: 10 to 50 years
Sex: All sexes can join.
Disease stage: Keratoconus seen at the refractive clinic. Back corneal surface height greater than 16 microns on Pentacam. ARTAve < 424 microns, ARTMax < 339 microns. Corneal thinning and astigmatism not caused by inflammation or injury.
Earlier treatment: People who have had eye surgery cannot join, including corneal collagen cross-linking.

Main reasons for not taking part

Wore contact lenses in the last four weeks
Poor eye focus or cannot cooperate with the exams
Past eye injury or eye surgery
Other eye diseases, such as corneal disease, glaucoma, retina or choroid disease, or severe dry eye, conjunctivitis or pterygium
Any body-wide disease that affects the shape or focusing parts of the eye

The registry criteria, word for word

Show all 2 criteriaShow less

Who can take part

① Patients with keratoconus who visit the refractive clinic; The height of the posterior corneal surface is greater than 16 microns under the Pentacam corneal topography; ARTAve < 424 microns, ARTMax < 339 microns; Clinical non-inflammatory or traumatic corneal thinning and corneal astigmatism; Aged between 10 and 50 years old, no gender restrictions; Agree to accept and complete follow-up examinations on time. ④ I and my guardian understand and agree to participate in this clinical trial and sign the informed consent form

Who cannot take part

① There is a history of contact lens wearing in the last four weeks; poor fixation and can not cooperate with the examination. ③ History of eye trauma and surgery (including corneal collagen cross-linking surgery); History of other related eye diseases: corneal disease, glaucoma, retinal choroid disease, etc; ⑤ severe eye diseases affecting imaging such as dry eye, conjunctivitis and pterygium; ⑥ Any systemic disease affecting eye morphology and refractive interstitium

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 10 and 50 years old?

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

The purpose of this observational study was to understand the differences in clinical features and mechanisms of keratoconus between children and adults. The main questions it aimed to answer as follows: (1) to understand the characteristics of keratoconus in Chinese children. (2) to observe corneal stromal cells at the cytological level using in vivo corneal laser confocal microscopy and explore the pathogenesis.