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Taking people in ItalyNo phase

Tracking Surgical Outcomes for Brain Vessel and Skull Base Conditions

Studies outcomes and their predictors in adults with brain aneurysms, malformations, and skull base tumors.

Key facts

Who runs it
Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Where
Bergamo, Brescia, Catania, Como, Cremona, Florence, Frosinone, Gravedona, Lecco, Legnano, Livorno, Milan, Monza, Palermo, Parma, Pavia, Roma, Rozzano, Sondrio, and Udine, ItalySee the 27 sites
Trial code
Registry title
Neurosurgical Outcome Network
Status
Recruiting
People taking part
4,500 people, planned
Started
5 Dec 2022
Expected to end
Jun 2027
Type of study
Observational
Record updated
30 March 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for people having neurosurgery for brain, skull base, blood vessel, spine, nerve, movement or pain conditions, or head injury. It studies surgery results and what predicts them.

Age
18 years or older.
Sex
All.
Disease stage
Brain or skull base tumors, aneurysms, AVMs, cavernomas, Moyamoya disease, dural fistulas, bleeding or hematomas in the head, hydrocephalus, spine conditions, Parkinson's disease, trigeminal neuralgia, drug-resistant epilepsy, peripheral nerve conditions, Chiari malformation type 1 and craniostenoses.

Main reasons for not taking part

  • For the thinking and mood assessment: a history of psychiatric disease or taking psychotropic drugs
  • For the thinking and mood assessment: obvious cognitive decline in the past not caused by the injury
  • For the thinking and mood assessment: under 18 years old

The registry criteria, word for word

Show all 10 criteriaShow less

Who can take part

  • Neuro-oncological pathology: supratentorial and subtentorial tumors, intra and extra axial tumors excluding the skull base (anterior, middle and posterior fossa; sellar and parasellar region)
  • Basicranial pathology: tumors originating from the anterior cranial fossa, middle cranial fossa and posterior cranial fossa, sellar region with or without supratentorial/parasellar development
  • Vascular pathology: aneurysms, AVMs, cavernomas, other pathologies (Moyamoya disease, dural fistulas, nontraumatic hematomas)
  • Traumatic pathology: diffuse damage (nonvisible diffuse damage, diffuse damage, diffuse damage with edema, diffuse damage with shift) and focal damage (acute/subacute/chronic subdural hematoma, extradural hematoma, subarachnoid hemorrhage, intraparenchymal hematoma, fractures); hydrocephalus. The inclusion criterion for chronic subdural hematoma is recent bleeding for TBI with CT finding of chronic subdural hematoma candidate for evacuation surgery
  • Spinal pathology: degenerative cervical (anterior/posterior), myelopathic, and trauma pathology; instrumented, uninstrumented thoracolumbar pathology (disc pathology, canal pathology), and trauma pathology; oncologic spinal pathology
  • Functional pathology: Parkinson's disease, spasticity, trigeminal neuralgia, craniofacial pain/algia, neuropathic pain, tremor, dystonias, obsessive compulsive disorder, drug-resistant epilepsies, depression. Normotensive hydrocephalus
  • Peripheral nervous system pathology: peripheral nerve compression syndromes, peripheral nerve and plexus tumors, brachial plexus and peripheral nerve trauma (contusion and section)
  • Malformative pathology: Chiari malformation type 1 and craniostenoses including both those framed in malformative syndromes and those not framed in malformative syndromes (monosutural craniostenoses: trigonocephaly, plagiocephaly, scaphocephaly; multisutural craniostenoses). Malformative hydrocephalus
  • For cognitive and psychological assessment: age 18 years or older; adequate understanding of Italian language; diagnosis of glioma, meningioma, vascular pathology, spinal pathology

Who cannot take part

  • For cognitive and psychological assessment: patients with psychiatric diseases in history and/or taking psychotropic drugs; presence of overt cognitive decline (not due to the injury) in history; patients younger than 18 years old

Where in Italy

  • 1. ASST Papa Giovanni XXIIIBergamo, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • Fondazione Poliambulanza Istituto OspedalieroBrescia, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • Spedali Civili BresciaBrescia, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • Azienda Ospedaliero Universitaria Policlinico "G. Rodolico - San Marco"Catania, ItalyContact: Giuseppe Barbagallo, MDTaking people
  • ASST Lariana, Ospedale S. AnnaComo, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • ASST CremonaCremona, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • Azienda Ospedaliero-Universitaria CareggiFlorence, ItalyContact: Alessandro Della Puppa, MDTaking people
  • Ospedale F. Spaziani di FrosinoneFrosinone, ItalyContact: Giancarlo D'Andrea, MDTaking people
  • Ospedale Moriggia PelasciniGravedona, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • Ospedale Alessandro ManzoniLecco, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • ASST Ovest MilaneseLegnano, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • Ospedali Riuniti di Livorno -Azienda USL Toscana nord ovestLivorno, ItalyContact: Gianluca Grimod, MDTaking people
  • Asst Santi Paolo E CarloMilan, ItalyContact: Marcello Egidi, MDTaking people
  • Fondazione IRCCS Istituto Neurologico Carlo BestaMilan, ItalyContact: Paolo Ferroli, MDTaking people
  • ASST Fatebenefratelli SaccoMilan, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • Fondazione IRCCS Cà Granda Ospedale Maggiore PoliclinicoMilan, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • Istituto Clinico Città StudiMilan, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • Policlinico di MonzaMonza, ItalyContact: Michele Incerti, MDTaking people
  • Fondazione IRCCS San Gerardo dei TintoriMonza, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • A.R.N.A.S. Ospedali Civico di PalermoPalermo, ItalyContact: Giovanni Tringali, MDTaking people
  • Azienda Ospedaliero Universitaria di ParmaParma, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • Fondazione IRCCS Policlinico San MatteoPavia, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • ASL Roma 1Roma, ItalyContact: Flavia Fraschetti, MDTaking people
  • Fondazione Policlinico Universitario Gemelli di RomaRoma, ItalyContact: Massimiliano Visocchi, MDTaking people
  • IRCCS Istituto Clinico HumanitasRozzano, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • ASST della Valtellina ed Alto LarioSondrio, ItalyContact: Paolo Ferroli, MDNo longer taking part
  • Azienda Sanitaria Universitaria Friuli Centrale di UdineUdine, ItalyContact: Marco Vindigni, MDTaking people

About the trial

What the trial wants to find out

The evaluation of neurosurgical outcomes varies from center to center, and the predictive factors that determine these outcomes are not fully known or shared. This study aims to assess outcomes and their predictors using measures agreed upon by the participating centers. Standardizing the evaluation of outcomes and predictors improves the quality of research, allows for data comparison, and facilitates a "common language" in routine clinical practice. Most importantly, it influences therapeutic decisions in various neurosurgical conditions. Clinically, the identified predictors can also be used during preoperative assessments to provide more precise guidance to patients undergoing surgery.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Neurosurgical Outcome Network Per la Predizione Dell'Outcome in Neurochirurgia
Plain-language title
Tracking Surgical Outcomes for Brain Vessel and Skull Base ConditionsGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
30 March 2026