Studies lung disease and early COPD signs in Chinese adults over one year
Follows people with COPD and early COPD signs over one year to learn more.
Plain-language title generated from the registry record
Registry title: A Translational Study for Prediction of Biomarkers and Identification of Phenotype and Endotype of COPD and Pre-COPD Outcomes in Chinese Population
Key facts
- Where
- Beijing, Changsha, Chengdu, Guangzhou, Hefei, Nanjing, Nanning, Shanghai, Shenyang, Wuhan, Xuzhou, and Zhengzhou, ChinaSee the 12 sites
Where in China
- BeijingBeijing, ChinaTaking people
- ChangshaChangsha, ChinaTaking people
- ChengduChengdu, ChinaTaking people
- GuangzhouGuangzhou, ChinaTaking people
- HefeiHefei, ChinaTaking people
- NanjingNanjing, ChinaTaking people
- NanningNanning, ChinaTaking people
- ShanghaiShanghai, ChinaTaking people
- ShenyangShenyang, ChinaNot yet recruiting
- WuhanWuhan, ChinaTaking people
- XuzhouXuzhou, ChinaTaking people
- ZhengzhouZhengzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- AstraZeneca
- Trial code
- NCT06724848
- Record updated
- 2 June 2026
- Original description
This is an observational study into more comprehensive understanding, including the trajectories of lung function decline, inflammatory/immunological mechanisms on pre-COPD or PRISm, clinical outcomes and relevant endotypes on physician-diagnosed COPD. The sponsor will follow up all participants for 1-year period.Read full original descriptionShow less
A Translational Study in Patients With COPD and Pre-COPD to Describe Patient Clinical Characteristics, Treatment Patterns, Biomarkers and to Identify Phenotypes and Endotypes Associated With Differential Outcomes That May Support Future Development of Personalized Treatment Strategies in Chinese Population
This is an observational study into more comprehensive understanding, including the trajectories of lung function decline, inflammatory/immunological mechanisms on pre-COPD or PRISm, clinical outcomes and relevant endotypes on physician-diagnosed COPD. The sponsor will follow up all participants for 1-year period.
Inclusion: Capable of giving signed ICF; Able to perform acceptable lung function testing for FEV1 according to American Thoracic Society and European Respiratory Society 2019 acceptability criteria; Able and willing to comply with the requirements of the protocol including ability to read, write, be fluent in the translated language of all participants facing questionnaires used at center; Participants will be allowed to enroll into other non-intervention studies while taking part in this study.
Exclusion: COPD exacerbation, within 2 weeks prior to enrollment or during screening period; History of partial or total lung resection (single lobe or segmentectomy is acceptable). Surgical or endoscopic (eg, valves) lung volume reduction within the 6 months prior to enrollment. Expected need for lung volume reduction surgery during the study; Malignancy, current or within the past 5 years, except for adequately treated non-invasive basal cell and squamous cell carcinoma of the skin and cervical carcinoma-in-situ treated with apparent success more than one year prior to enrollment. Suspected malignancy or undefined neoplasms; Participants receipt marketed or investigational biologics biologics within 3 months or 5 half-lives prior to visit 1, whichever is longer; The participant has a history of alcohol or drug abuse within the past year, which, in the opinion of the responsible physician, contra-indicates their participation; Clinically important pulmonary disease; Unstable disorders; Terminal disease and/or organ failure or participants otherwise considered not appropriate for the study participation; Clinically significant abnormal laboratory values available vital signs, ECG, or laboratory testing at the screening assessment that, which in the opinion of the investigator, could interfere with the objectives of the study or safety of the participant. -Current diagnosis of asthma; The participant has an altered mental status at the time of informed consent; Female participants who are pregnant.