Studies combined CYTOFLAVIN therapy in patients recovering from intensive care syndrome
Observes a combined CYTOFLAVIN treatment in adults recovering from post intensive care syndrome.
Plain-language title generated from the registry record
Registry title: Evaluation of the Efficacy of Permanent Course Combined Therapy With CYTOFLAVIN® Intravenous Solution and CYTOFLAVIN Tablets, at 2-3 Stages of Rehabilitation of Patients With Post Intensive Care Syndrome
Key facts
- Where
- Yekaterinburg, RussiaSee the site
Where in Russia
- Brain Institute ClinicYekaterinburg, RussiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- POLYSAN Scientific & Technological Pharmaceutical Company
- Trial code
- NCT06735898
- Record updated
- 6 April 2025
- Original description
Post intensive care syndrome (PIC syndrome) is an important problem in modern intensive care strategy. Understanding the mechanisms of PIC syndrome helps prevent it in patients with respiratory, neuromuscular transmission, and cognitive impairments that require prolonged support of vital functions. Significant role in the formation and severity of PIC syndrome is played by the severity of the systemic inflammatory response, which is an individual reaction of the body, and this determines the degree of neurological and psychological deficits. Chronic diseases such as diabetes mellitus, especially in the context of metabolic syndrome, worsen the course of PIC syndrome and delays recovery. Early initiation of rehabilitation measures in the intensive care unit and subsequent expansion of the individual rehabilitation program contributes to the rapid and successful recovery of not only vital functions, but also cognitive, motor and emotional disorders. This shortens the hospital stay of patient and improves their quality of life after discharge.Read full original descriptionShow less
Evaluation of the Efficacy of Permanent Course Combined Therapy With CYTOFLAVIN® Intravenous Solution and CYTOFLAVIN® Tablets, at 2-3 Stages of Rehabilitation of Patients With Post Intensive Care Syndrome
Post intensive care syndrome (PIC syndrome) is an important problem in modern intensive care strategy. Understanding the mechanisms of PIC syndrome helps prevent it in patients with respiratory, neuromuscular transmission, and cognitive impairments that require prolonged support of vital functions. Significant role in the formation and severity of PIC syndrome is played by the severity of the systemic inflammatory response, which is an individual reaction of the body, and this determines the degree of neurological and psychological deficits. Chronic diseases such as diabetes mellitus, especially in the context of metabolic syndrome, worsen the course of PIC syndrome and delays recovery. Early initiation of rehabilitation measures in the intensive care unit and subsequent expansion of the individual rehabilitation program contributes to the rapid and successful recovery of not only vital functions, but also cognitive, motor and emotional disorders. This shortens the hospital stay of patient and improves their quality of life after discharge.
Inclusion: Men and women over 18 years of age and older; Stay in the ITU and (or) intensive care unit for at least 3 days; Diagnosed "post intensive care" syndrome (PIC syndrome) with moderate-to-severe severity >3<6 points; Diagnosed modalities "critical illness polyneuropathy, respiratory neuropathy, dysphagia" of the domain "Neuromuscular complications" of PIC syndrome at 2-3 stages of the rehabilitation route at any value of PICS severity index; Diagnosed modalities "decreased gravitational gradient, decreased exercise tolerance" in the domain "Vegetative-metabolic complications" at 2-3 stages of the rehabilitation route at any value of PICS severity index.
Exclusion: Use of drugs from "metabolic agents" pharmacotherapeutic group at the time of inclusion in the study; Acute cardiac failure; Acute respiratory failure; Acute renal failure; Acute liver cell failure; Life expectancy of 6 months or less or presence of incurable diseases in decompensation stage; Hemoglobin level ≤80 g/L; Premorbid level of vital activity when assessed on the rehabilitation routing scale 4-5 points; Hematocrit ≤30%.