Tests high-dose vitamin D for seizures, fatigue, and quality of life in epilepsy
Tests high-dose vitamin D against placebo in people with epilepsy.
Plain-language title generated from the registry record
Registry title: Effects of Mega-dose Vitamin D Pulse and Maintenance Therapy on Seizure Frequency, Fatigue, and Quality of Life: A Prospective Study
Key facts
- Where
- Tainan, TaiwanSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with epilepsy to test whether high-dose vitamin D changes seizure frequency, tiredness and quality of life.
- Age
- 20 years or older
- Sex
- All sexes can join.
- Disease stage
- People with a diagnosis of epilepsy. Refractory epilepsy means seizures stay poorly controlled after more than two drugs at standard doses.
- Earlier treatment
- For refractory epilepsy: more than two drugs used, each at a standard reasonable dose.
Main reasons for not taking part
- Imaging shows brain damage that persisted or grew in the past three years
- Cannot follow the trial plan and take vitamin D, and has no family member or caregiver who can help
Read by machine on 9 November 2026.
Where in Taiwan
- National Cheng Kung University HospitalTainan, TaiwanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Chin-Wei Huang
- Trial code
- NCT06736002
- Record updated
- 13 April 2026
- Original description
This prospective study aims to evaluate the effects of mega-dose vitamin D pulse therapy followed by maintenance therapy on seizure frequency, fatigue, and quality of life in patients with epilepsy. Participants will receive vitamin D supplementation, and clinical outcomes will be assessed over time to determine its potential benefits on seizure control and patient-reported outcomes.Read full original descriptionShow less
Effects of Mega-dose Vitamin D Pulse and Maintenance Therapy on Seizure Frequency, Fatigue, and Quality of Life: A Prospective Study
This prospective study aims to evaluate the effects of mega-dose vitamin D pulse therapy followed by maintenance therapy on seizure frequency, fatigue, and quality of life in patients with epilepsy. Participants will receive vitamin D supplementation, and clinical outcomes will be assessed over time to determine its potential benefits on seizure control and patient-reported outcomes.
Inclusion: Aged 20 or above (inclusive); Diagnosed patients (refractory epilepsy refers to those who have used more than two drugs, and each drug has reached the When epileptic seizures cannot be well controlled at standard reasonable treatment doses, it is called refractory epilepsy); There is no imaging evidence of persistence or expansion of brain damage in the past three years; Subjects or family members (caregivers) can comply with the trial plan and take vitamin D patients.
Exclusion: -.