Ketamine Effects on Learning In Eating Disorders

Who can take part

• Age 16-26 years old
• Meets diagnosis of anorexia nervosa (AN) or atypical anorexia nervosa (atypical AN) per DSM-5 criteria on admission
• Admitted to the medical hospital for malnutrition
• No changes to psychiatric medications for month prior to trial enrollment
• Agree to use a highly effective form of contraception for at least two weeks following ketamine administration
• Have an outpatient primary care provider, medical provider, or behavioral health provider or psychiatrist who is actively managing or coordinating care

Who cannot take part

• Electroconvulsive therapy (ECT) or transcranial magnetic stimulation (TMS) treatment within 30 days prior to enrollment
• Taking medications that would be unsafe to administer with ketamine
• Lifetime history of any psychotic disorder
• Moderate or severe substance use disorder
• Biochemical refeeding syndrome or electrolyte abnormality
• Cardiac abnormalities identified on admission
• Other medical condition or diagnosis, physical exam finding, laboratory abnormality, or health risk that would increase the risk of adverse events, at the discretion of the investigators
• Pregnancy as indicated by a positive urine pregnancy test during screening, lactation, or the intention of becoming pregnant within 3 months of entry into this trial
• Intellectual or developmental disability
• High risk for self-harm/suicide
• Active laxative misuse or abuse