Tests acupuncture with nerve growth factor for swallowing trouble after stroke
Tests electroacupuncture with a nerve growth factor injection in adults with swallowing difficulty after stroke.
Plain-language title generated from the registry record
Registry title: Effect of Specific Mode Electroacupuncture Stimulation Combined with NGF on Dysphagia After Ischaemic Stroke: a Pilot Randomized Controlled Trial
Key facts
- Where
- Hangzhou, ChinaSee the site
- Phase
- Phase 4
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06737549, who can take part
Where in China
- the Third Affiliated Hospital of Zhejiang Chinese Medical UniversityHangzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The Third Affiliated hospital of Zhejiang Chinese Medical University
- Trial code
- NCT06737549
- Record updated
- 17 December 2024
- Original description
Ischemic stroke is a common clinical disease, often accompanied by dysphagia. At present, clinical treatment for patients with dysphagia after ischemic stroke is limited. The emergence of NGF has surprised the field of neurorehabilitation, but the clinical effect is not satisfactory. The main problem is that NGF is a macromolecular material with a molecular weight of 13.4 KD, which is difficult to penetrate the blood brain barrier. A large number of previous studies in our team have found that electroacupuncture with specific stimulation mode can open the blood brain barrier and induce NGF into the brain. Therefore, the purpose of this study is to investigate the effect of specific mode electroacupuncture stimulation combined with NGF treatment on patients with dysphagia after ischemic stroke and to explore the mechanism of this combination therapy to improve brain function, which creates a new method and theoretical basis for nerve rehabilitation of integrated traditional Chinese and Western medicine.Read full original descriptionShow less
Effect of Specific Mode Electroacupuncture Stimulation Combined with NGF on Dysphagia After Ischaemic Stroke: a Pilot Randomized Controlled Trial
Ischemic stroke is a common clinical disease, often accompanied by dysphagia. At present, clinical treatment for patients with dysphagia after ischemic stroke is limited. The emergence of NGF has surprised the field of neurorehabilitation, but the clinical effect is not satisfactory. The main problem is that NGF is a macromolecular material with a molecular weight of 13.4 KD, which is difficult to penetrate the blood brain barrier. A large number of previous studies in our team have found that electroacupuncture with specific stimulation mode can open the blood brain barrier and induce NGF into the brain. Therefore, the purpose of this study is to investigate the effect of specific mode electroacupuncture stimulation combined with NGF treatment on patients with dysphagia after ischemic stroke and to explore the mechanism of this combination therapy to improve brain function, which creates a new method and theoretical basis for nerve rehabilitation of integrated traditional Chinese and Western medicine.
Inclusion: Patients with first-ever ischemic stroke confirmed by Computed Tomography (CT) and/or Magnetic Resonance Imaging (MRI); Onset time ranged from 15 days to 180 days; Aged 18 to 80 years old, male or female; Dysphagia confirmed by a videofluoroscopic swallowing study (VFSS); Patients who are able to accept and comply with acupuncture, electroacupuncture treatment, gluteal intramuscular injection, and have good compliance; Have provided signed consent and exhibit willingness to participate in the trial; Women who are lactating, pregnant or intending to get pregnant.
Exclusion: Patients with severe neurological deficits prior to ischemic stroke, such as visual and auditory impairments, aphasia, agnosia, severe hemiplegia, and other conditions; Patients with a medication history that may alter cortical excitability within the past 2 months; Patients with dysphagia before ischemic stroke onset or dysphagia not caused by ischemic stroke; Patients with severe cognitive impairment; Patients with severe cardiac, hepatic, and renal dysfunction, as well as severe coagulation abnormalities; Multiple occurrences of stroke, or a history of craniocerebral surgery, or cerebral infarction caused by trauma or brain tumors; Patients with a history of needle fainting or with skin infections at the acupuncture site; Cardiac pacemaker carrier; Patients allergic to NGF; Patients with other abnormal test results who are deemed unsuitable to participate in this study by the investigator; Women who are lactating, pregnant or intending to get pregnant; The inability to undergo VFSS; Patients who are currently participating in other clinical trials or have participated in clinical trials that ended within the last 3 months.