Studies autonomic nerve problems in people after an ischemic stroke
Looks at nerve control of heart and body in stroke and mini-stroke patients.
Plain-language title generated from the registry record
Registry title: Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke
Key facts
- Where
- Hamburg, GermanySee the site
Where in Germany
- University Medical Center Hamburg-EppendorfHamburg, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universitätsklinikum Hamburg-Eppendorf
- Trial code
- NCT06740942
- Record updated
- 7 May 2026
- Original description
The goal of this observational study is toRead full original descriptionShow less
Imaging and Serological Biomarkers of Autonomic Dysfunction After Ischemic Stroke
The goal of this observational study is to
* to investigate the prevalence and time course of autonomic dysfunction in acute ischemic stroke patients; * to evaluate the influence of lesion location on autonomic dysfunction; * to identify patterns of structural and functional brain connectivity within the central autonomic control circuits associated with autonomic dysfunction; and * to explore causal models of the link between brain lesions; cardiac, immunological and endocrine biomarkers; and dysautonomia.
Researchers will compare patients with acute ischemic stroke to patients with transient ischemic attacks to study the effect of acute ischemic brain lesions.
Participants will
* undergo cardiovascular autonomic function testing; * receive structural and functional MR imaging; * provide blood samples for determinaton of serological biomarkers auf dysautonomia.
Inclusion: Diagnosis of either; acute ischemic stroke with either an ischemic lesion visible on CT/MRI or persistent focal deficits 24 hours after symptom onset, or; Transient ischemic attack with transient clinical deficits including motor or speech disturbance and not restricted to isolated vertigo/dizziness, visual disturbance, or sensory disturbance; symptom onset within 72h prior to hospital admission,; a pre-stroke/TIA ability to walk without help from another person (modified Rankin scale score < 4),; age > 18 years, and; informed consent by either the patient or a legal representative (including a spouse).
Exclusion: contraindications to MR imaging (e.g., claustrophobia, pregnancy, pacemakers, implants),; previous structural brain damage (except leukoariosis due to cerebral small vessel disease),; concomitant systemic illness that can lead to dysautonomia, such as an active infection, thyroid disease, or neurodegenerative disorder (e.g. PD, MSA); In-hospital stroke,; known moderate to severe dementia,; left heart failure with estimated left ventricular ejection fraction < 50%,; hemodynamically relevant stenosis of the common or internal carotid artery, or.