Taking people in United StatesNo phase

Trial in Arrhythmia Radioablation for Ventricular Tachycardia: Single Fraction vs Three Fractions

Key facts

Who runs it: Weill Medical College of Cornell University
Where: New York, United StatesSee the site
Trial code: NCT06743789
Status: Recruiting
People taking part: 40 people, planned
Started: 18 Dec 2024
Expected to end: Dec 2030
Type of study: Interventional, 6 groups
Treatments tested: Radiation Therapy
Record updated: 26 January 2026

Who can take part

Age: 18 years to 90 years
Sex: Women and men
Healthy volunteers: Cannot take part

The registry criteria, word for word

Show all 9 criteriaShow less

Who can take part

Age ≥ 18 years
Structural heart disease:; Ischemic cardiomyopathy; Non-ischemic cardiomyopathy; Hypertrophic cardiomyopathy
Refractory VT severity:; VT leading to ICD shock with minimum 3 episodes in any 3-month period without reversible cause; Failed or intolerant to antiarrhythmic drug therapy (either amiodarone or ≥ 2 AADs) AND failed ablation (CA); OR ablation (CA) contraindicated
Ability to understand study protocol and to write informed consent
Willing to comply with specified pre-, post- and follow-up testing, evaluations and requirements
Expected to remain available for at least 36 months after enrollment

Who cannot take part

Prior chest radiation therapy
Age < 18 years
Pregnancy

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 90 years old?

Where in United States

Weill Cornell MedicineNew York, United StatesContact: Fabiana Gregucci, M.DTaking people

About the trial

What the trial wants to find out

This is a research study that aims to understand if giving a lower dose of treatment all at once is as effective and safe as dividing it into three smaller doses for patients with a heart condition called refractory ventricular tachycardia (VT). These patients have not exhibited positive responses to conventional medications or procedures. This study aims to explore whether an alternative approach could yield more beneficial outcomes.

The 6 groups in the trial

20 Gy Radiation Dose (Arm 1 Group 1)Treatment being tested
Arm 1: Group 1 (3 participants) - will receive a dose of 20 Gy ("Gray", a measurement of radiation) in a single study intervention (one study intervention day)
Treatment: Radiation Therapy
15 Gy Radiation Dose (Arm 1 Group 2)Treatment being tested
Arm 1: Group 2 (3 participants) - will receive a dose of 15 Gy in a single study intervention (one study intervention day)
Treatment: Radiation Therapy
10 Gy Radiation Dose (Arm 1 Group 3)Treatment being tested
Arm 1: Group 3 (3 participants) - will receive a dose of 10 Gy in a single study intervention (one study intervention day)
Treatment: Radiation Therapy
12 Gy Radiation Dose for 3 fractions (Arm 2 Group 1)Treatment being tested
Arm 2: Group 1 (3 participants) - will receive a dose of 12 Gy ("Gray", a measurement of radiation) given over 3 days (Days 1, 2 and 3). (Total radiation dose = 36Gy)
Treatment: Radiation Therapy
10 Gy Radiation Dose for 3 fractions (Arm 2 Group 2)Treatment being tested
Arm 2: Group 2 (3 participants) - will receive a dose of 10 Gy ("Gray", a measurement of radiation) given over 3 days (Days 1, 2 and 3). (Total radiation dose = 30Gy)
Treatment: Radiation Therapy
8Gy Radiation Dose for 3 fractions (Arm 2 Group 3)Treatment being tested
Arm 2: Group 3 (3 participants) - will receive a dose of 8 Gy ("Gray", a measurement of radiation) given over 3 days (Days 1, 2 and 3). (Total radiation dose = 24Gy)
Treatment: Radiation Therapy