Radiation given at once or split up for hard-to-treat ventricular tachycardia
Compares single versus split radiation doses for ventricular tachycardia.
Key facts
- Who runs it
- Weill Medical College of Cornell University
- Where
- New York, United StatesSee the site
- Trial code
- Registry title
- Trial in Arrhythmia Radioablation for Ventricular Tachycardia: Single Fraction vs Three Fractions
- Status
- Recruiting
- People taking part
- 40 people, planned
- Started
- 18 Dec 2024
- Expected to end
- Dec 2030
- Type of study
- Interventional, 6 groups
- Treatments tested
- Radiation Therapy
- Record updated
- 26 January 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with structural heart disease and ventricular tachycardia (a dangerous fast heart rhythm) that has not responded to usual treatments. It compares radiation given in one session with radiation given over three days.
- Age
- 18 Years to 90 Years
- Sex
- All sexes can join.
- Disease stage
- Refractory ventricular tachycardia, which means it keeps coming back despite treatment. People must have ischemic, non-ischemic or hypertrophic cardiomyopathy (heart muscle disease). The VT must have caused ICD shocks at least 3 times in any 3-month period, with no reversible cause.
- Earlier treatment
- Antiarrhythmic drugs (amiodarone or at least 2 such drugs) must have failed or not been tolerated, and catheter ablation must have failed. People who cannot have catheter ablation can also join.
Main reasons for not taking part
- Under 18 years old
- Pregnancy
- Earlier radiation therapy to the chest
- Not able to stay available for at least 36 months after joining
- Not able to follow the study tests and visits
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Age ≥ 18 years
- Structural heart disease:; Ischemic cardiomyopathy; Non-ischemic cardiomyopathy; Hypertrophic cardiomyopathy
- Refractory VT severity:; VT leading to ICD shock with minimum 3 episodes in any 3-month period without reversible cause; Failed or intolerant to antiarrhythmic drug therapy (either amiodarone or ≥ 2 AADs) AND failed ablation (CA); OR ablation (CA) contraindicated
- Ability to understand study protocol and to write informed consent
- Willing to comply with specified pre-, post- and follow-up testing, evaluations and requirements
- Expected to remain available for at least 36 months after enrollment
Who cannot take part
- Prior chest radiation therapy
- Age < 18 years
- Pregnancy
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 90 years old?
Where in United States
- Weill Cornell MedicineNew York, United StatesContact: Fabiana Gregucci, M.DTaking people
About the trial
What the trial wants to find out
This is a research study that aims to understand if giving a lower dose of treatment all at once is as effective and safe as dividing it into three smaller doses for patients with a heart condition called refractory ventricular tachycardia (VT). These patients have not exhibited positive responses to conventional medications or procedures. This study aims to explore whether an alternative approach could yield more beneficial outcomes.
The 6 groups in the trial
- 20 Gy Radiation Dose (Arm 1 Group 1)Treatment being tested
Arm 1: Group 1 (3 participants) - will receive a dose of 20 Gy ("Gray", a measurement of radiation) in a single study intervention (one study intervention day)
Treatment: Radiation Therapy
- 15 Gy Radiation Dose (Arm 1 Group 2)Treatment being tested
Arm 1: Group 2 (3 participants) - will receive a dose of 15 Gy in a single study intervention (one study intervention day)
Treatment: Radiation Therapy
- 10 Gy Radiation Dose (Arm 1 Group 3)Treatment being tested
Arm 1: Group 3 (3 participants) - will receive a dose of 10 Gy in a single study intervention (one study intervention day)
Treatment: Radiation Therapy
- 12 Gy Radiation Dose for 3 fractions (Arm 2 Group 1)Treatment being tested
Arm 2: Group 1 (3 participants) - will receive a dose of 12 Gy ("Gray", a measurement of radiation) given over 3 days (Days 1, 2 and 3). (Total radiation dose = 36Gy)
Treatment: Radiation Therapy
- 10 Gy Radiation Dose for 3 fractions (Arm 2 Group 2)Treatment being tested
Arm 2: Group 2 (3 participants) - will receive a dose of 10 Gy ("Gray", a measurement of radiation) given over 3 days (Days 1, 2 and 3). (Total radiation dose = 30Gy)
Treatment: Radiation Therapy
- 8Gy Radiation Dose for 3 fractions (Arm 2 Group 3)Treatment being tested
Arm 2: Group 3 (3 participants) - will receive a dose of 8 Gy ("Gray", a measurement of radiation) given over 3 days (Days 1, 2 and 3). (Total radiation dose = 24Gy)
Treatment: Radiation Therapy
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Dose De-escalation Randomized Phase I/II Trial in Arrhythmia Radioablation for Ventricular Tachycardia: Single Fraction vs Three Fractions
- Plain-language title
- Radiation given at once or split up for hard-to-treat ventricular tachycardiaGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Fit questions
- Built from NCT06743789, who can take part
- Record updated
- 26 January 2026