Early detection of Parkinson's disease through peripheral nerve changes
Studies a method to spot early Parkinson's-type disease in adults with nerve damage.
Plain-language title generated from the registry record
Registry title: Prodromal Model of Parkinson's Disease Confined to The Peripheral Nervous System
Key facts
- Where
- Aarhus, DenmarkSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 85 with nerve damage in the limbs (polyneuropathy) of unknown cause, plus a blood pressure problem. It aims to find Parkinson's-type disease at an early stage.
- Age
- 18 to 85 years
- Sex
- All sexes can join.
- Disease stage
- Definite polyneuropathy with no known cause, together with orthostatic hypotension (blood pressure drop when standing) or no normal blood pressure drop at night.
Main reasons for not taking part
- Polyneuropathy with a known cause
- Diagnosis of dementia
- Diagnosis of Parkinson's disease
- Diagnosis of Dementia with Lewy Bodies
- Diagnosis of Multiple System Atrophy
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT06745011, who can take part
Where in Denmark
- Institute of Clinical Medicine, Aarhus UniversityAarhus, DenmarkNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Aarhus
- Trial code
- NCT06745011
- Record updated
- 8 January 2025
- Original description
Description of a method to detect Parkinson's disease or Parkinson's-like disease at an early stage (Prodromal Parkinson's Disease) where damage is still confined to the peripheral nervous system damage. Simultaneous collection of biological material to establish a biobank for use as prognostic biomarkers for the development of Parkinson's disease and other neurodegenerative diseases in which pathological alpha-synuclein deposits accumulate.Read full original descriptionShow less
Prodromal Model of Parkinson's Disease Confined to The Peripheral Nervous System
Description of a method to detect Parkinson's disease or Parkinson's-like disease at an early stage (Prodromal Parkinson's Disease) where damage is still confined to the peripheral nervous system damage. Simultaneous collection of biological material to establish a biobank for use as prognostic biomarkers for the development of Parkinson's disease and other neurodegenerative diseases in which pathological alpha-synuclein deposits accumulate.
Inclusion: Definite polyneuropathy without known etiology (idiopathic) AND orthostatic hypotension (active stand test) OR non-nocturnal blood pressure reduction (24 hour blood pressure measurement).
Exclusion: A diagnosis of either dementia, Parkinson's disease, Dementia with Lewy Bodies or Multiple System Atrophy; Known etiology of polyneuropathy.