Compares two heart-rhythm procedures for persistent atrial fibrillation in adults
Compares pulsed field ablation with radiofrequency ablation in adults with persistent atrial fibrillation.
Plain-language title generated from the registry record
Registry title: Comparative Efficacy and Safety of Extensive Electro-Anatomical Guided Pulsed Field Ablation Versus Radiofrequency Ablation in Persistent Atrial Fibrillation
Key facts
- Where
- Shanghai, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with persistent atrial fibrillation (an irregular heartbeat that lasts) who got no benefit from, or could not tolerate, at least one rhythm-control medicine.
- Age
- 18 to 80 years
- Sex
- Women and men can both join.
- Disease stage
- Persistent atrial fibrillation.
- Earlier treatment
- Must have had no benefit from, or not tolerated, at least one Class I or III anti-arrhythmic drug.
Main reasons for not taking part
- Major valve disease that needs surgery
- Blood clot in the left atrium on recent imaging
- Recent heart attack
- Severe heart failure (LVEF 30% or lower)
- Current severe infection
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06745167, who can take part
Where in China
- No. 241, West Huaihai RoadShanghai, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Shanghai Chest Hospital
- Trial code
- NCT06745167
- Record updated
- 20 December 2024
- Original description
This multicenter, randomized controlled trial aims to compare the efficacy and safety of extensive electro-anatomical guided pulsed field ablation (EXT-PFA) with traditional radiofrequency ablation (RF) in treating persistent atrial fibrillation (PeAF). The trial seeks to determine if EXT-PFA, which integrates anatomical and electrogram-guided strategies, can provide superior outcomes in terms of safety and effectiveness compared to the standard RF ablation approach.Read full original descriptionShow less
Comparative Efficacy and Safety of Electro-Anatomical Guided Pulsed Field Ablation Versus Radiofrequency Ablation in the Treatment of Persistent Atrial Fibrillation: A Randomized Controlled Trial
This multicenter, randomized controlled trial aims to compare the efficacy and safety of extensive electro-anatomical guided pulsed field ablation (EXT-PFA) with traditional radiofrequency ablation (RF) in treating persistent atrial fibrillation (PeAF). The trial seeks to determine if EXT-PFA, which integrates anatomical and electrogram-guided strategies, can provide superior outcomes in terms of safety and effectiveness compared to the standard RF ablation approach.
Inclusion: 1.Adults aged 18-80 years diagnosed with persistent atrial fibrillation. 2.Ineffectiveness or intolerance to at least one Class I or III anti-arrhythmic drug.
Exclusion: Major valvular diseases needing surgical intervention; Current Severe Infection; Recent myocardial infarction or severe heart failure (LVEF ≤ 30%); Presence of a left atrial thrombus on recent imaging.