Studying why depression returns after recovery in adults
Watches adults with recovered depression to learn when symptoms may return.
Plain-language title generated from the registry record
Registry title: Predictors of Relapse in Major Depressive Disorder (PERFORM-D)
Key facts
- Where
- Calgary, Halifax, Hamilton, Kingston, Ottawa, Toronto, Vancouver, and Whitby, CanadaSee the 9 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT06746155, who can take part
Where in Canada
- University Of CalgaryCalgary, CanadaTaking people
- Nova Scotia HealthHalifax, CanadaTaking people
- McMaster UniversityHamilton, CanadaTaking people
- Queen's UniversityKingston, CanadaTaking people
- The Royal Ottawa Mental Health CentreOttawa, CanadaNot yet recruiting
- Centre for Addiction and Mental Health (CAMH)Toronto, CanadaTaking people
- University Health NetworkToronto, CanadaTaking people
- University of British ColumbiaVancouver, CanadaTaking people
- Ontario Shores Centre for Mental Health SciencesWhitby, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Abraham Nunes
- Trial code
- NCT06746155
- Record updated
- 10 July 2026
- Original description
Major depressive disorder (MDD) is a common condition involving recurring periods of depression. One of the major challenges faced by people with MDD is that the episodes of depression tend to recur even after they are successfully treated. Currently, it is hard to predict when a depressive episode will recur. Being able to forecast this would help healthcare providers monitor patients and prevent relapse.Read full original descriptionShow less
Predictors of Early Relapse During Follow-up Of Remitted Major Depression
Major depressive disorder (MDD) is a common condition involving recurring periods of depression. One of the major challenges faced by people with MDD is that the episodes of depression tend to recur even after they are successfully treated. Currently, it is hard to predict when a depressive episode will recur. Being able to forecast this would help healthcare providers monitor patients and prevent relapse.
The purpose of this study is to monitor features such as clinical symptoms, physical activity, sleep patterns, cognitive functioning and brain activity to help us understand how relapse happens and the mechanisms that cause it. From these different types of data, investigators will build a model that tells us who is more likely to experience a relapse and when the relapse is likely to occur.
This study will be a significant step forward in understanding and managing MDD. Investigator will create a practical tool that will allow healthcare providers to monitor patients more effectively. By identifying early signs of relapse, investigators may be able to intervene promptly to prevent depressive episodes. Finally, our research will help understand the factors that underlie relapse in MDD, which will encourage the development of novel treatment approaches.
Inclusion: Outpatients 18 to 70 years of age; Meet DSM-V criteria for MDD as determined by the SCID-5 or other standardized clinical interviews; In the current or most recent MDE, participant must be responding or responded to a treatment or a combination of treatments for MDD. Patients with remitted MDD who are currently not taking medications will also be accepted. Patients must have achieved remission at or later than May 1, 2023; Participants must have a MADRS total score ≤14; Participant must be willing and able to complete self-reported assessments including sufficient fluency in English; Participant must be willing to wear the wrist-worn actigraphic device for the duration of the study.
Exclusion: Bipolar I or Bipolar-II diagnosis (lifetime), schizophrenia, or schizoaffective disorder; Existence of major neurological disorders, head injury (if accompanied by any of [A] loss of consciousness longer than 24 hours, [B] documented evidence of Glasgow Coma Scale <9 at the time of injury, [C] post-traumatic amnesia lasting longer than 24 hours) (43), or other unstable medical conditions; The participant presents with any condition which, according to the researcher's judgment, could interfere with the assessments stipulated in the protocol; Elevated risk of suicide, as determined by clinical evaluation; The participant is employed by the researcher, actively involved in the current study or other research overseen by the same researcher, or is a relative of a study employee or the researcher.