Enrolling by invitationNo phase

Freezing treatment for brain tumors, checked for safety and practicality

Tests cryoablation, a freezing procedure, in adults with brain tumors.

Key facts

Who runs it: Erasmus Medical Center
Where: Netherlands1 site in 1 countryChoose a country to see its sites
Trial code: NCT06753617
Registry title: Cryoablation of Brain Neoplasm
Status: Enrolling by invitation
People taking part: 20 people, planned
Started: 17 Oct 2023
Planned end: May 2025
Type of study: Interventional
Treatments tested: Cryoablation of brain neoplasm
Record updated: 31 December 2024

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with a suspected brain tumor who will have surgery. During surgery, the tumor will also be frozen (cryoablation).

Age: Over 18 years, up to 80 years.
Sex: All sexes can join.
Disease stage: Suspected glioma (astrocytoma, oligodendroglioma or glioblastoma), meningioma (WHO grade 1 or 2) or brain metastasis. The tumor can be in the upper or lower part of the brain. A safe path must allow freezing at least 70% of the tumor. Karnofsky performance score must be 70 or more, meaning people can care for themselves.
Biomarker or test result: For glioma: astrocytoma IDH mutant, oligodendroglioma IDH-mutant and 1p/19q-codeleted, or glioblastoma IDH-wildtype.

Main reasons for not taking part

Tumor diameter bigger than 10 cm (3.9 in)
No safe path without risk to key brain areas
Pregnancy
Cannot have general anesthesia
Not enough knowledge of Dutch to understand the study documents

The registry criteria, word for word

Show all 12 criteriaShow less

Who can take part

Age >18 years
Tumor suspected as glioma (1. Astrocytoma, IDH mutant 2. Oligodendroglioma, IDH-mutant and 1p/19q-codeleted 3. Glioblastoma, IDH-wildtype), meningioma (WHO gr. 1 and gr 2), or brain metastasis based on preliminary diagnosis for which the patient will undergo surgery
Supratentorial or infratentorial localization
Safe trajectory/trajectories possible for ablation of at least 70% of the tumor, avoiding eloquent structures
Karnofsky performance scale 70 or more
Sufficient knowledge of the Dutch language to understand the study documents (in the judgement of the attending physician or researcher)
Written Informed consent

Who cannot take part

<18 years or >80 years
Tumor diameter bigger than 10 cm
Unsafe trajectory (eloquent structures could be damaged)
Pregnancy
Contra-indication for general anesthesia

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 80 years old?

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

This study will investigate the use of safety and feasibility of cryoablation in brain tumors

The group in the trial

Cryoablation Treatment GroupTreatment being tested
All patients enrolled in this study will undergo cryoablation as part of their surgical tumor resection procedure. The intervention will be integrated into the standard surgical approach.
Treatment: Cryoablation of brain neoplasm