Toll-like Receptor-4 Gene Variant and Gum Disease in Kidney Failure Patients
Studies a gene variant of Toll-like receptor-4 in kidney failure patients with gum disease.
Plain-language title generated from the registry record
Registry title: The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population
Key facts
- Where
- Al Fayyum, EgyptSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 30 and 60 years old?
Source: NCT06755372, who can take part
Where in Egypt
- hemodialysis center at Benha University Hospital.Al Fayyum, EgyptTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Ain Shams University
- Trial code
- NCT06755372
- Record updated
- 4 July 2025
- Original description
Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications. Periodontitis is linked to systemic diseases, including renal disease, with inflammation playing a key role. TLR4 genetic variations may influence susceptibility to CKD and periodontitis. This study investigates the association between TLR4 [Gly/Thr (rs2149356)] polymorphism and chronic periodontal disease in ESRD patients in Egypt.Read full original descriptionShow less
The Role of Toll-like Receptor-4 in Periodontitis Patients With End-stage Renal Disease in a Sample of Egyptian Population
Chronic kidney disease (CKD) is a significant public health issue in Egypt, leading to end-stage renal disease (ESRD). ESRD patients often suffer from oral abnormalities due to the disease and medications. Periodontitis is linked to systemic diseases, including renal disease, with inflammation playing a key role. TLR4 genetic variations may influence susceptibility to CKD and periodontitis. This study investigates the association between TLR4 [Gly/Thr (rs2149356)] polymorphism and chronic periodontal disease in ESRD patients in Egypt.
Inclusion: Age: 30 to 60 years; Gender: Both male and female; Diagnosed with Periodontitis stage II and/or stage III; Systemically healthy, no history of systemic diseases; Not on long-term medications; Age: 30 to 60 years; Gender: Both male and female; Diagnosed with end-stage renal disease (ESRD) on regular hemodialysis; Diagnosed with Periodontitis stage II and/or stage III; Unrelated Egyptians from a similar socioeconomic status, residing in the same geographical area; Underlying type 2 diabetes mellitus.
Exclusion: Individuals with any systemic disease or long-term medication use; Individuals with systemic diseases other than diabetes; History of malignancy; Smokers; Group II: ESRD Patients with Periodontitis; Individuals with kidney transplants; Smokers.
Group I: Healthy Subjects with Periodontitis.