Testing an added blood-thinning drug after a stroke from narrowed large arteries
Tests cilostazol added to standard blood thinners in adults with stroke from artery narrowing.
Plain-language title generated from the registry record
Registry title: The Effect and Safety of Combined Anti-platelet Treatment in Acute Ischemic Stroke Due to Large Artery Atherosclerosis
Key facts
- Where
- Busan, Cheongju-si, Daegu, Daejeon, Gwangju, Gyeonggi-do, Incheon, Jeju City, Jeonju, Seoul, and Yangsan, South KoreaSee the 24 sites
- Phase
- Phase 4
Where in South Korea
- Pusan National University HospitalBusan, South KoreaTaking people
- Chungbuk National University HospitalCheongju-si, South KoreaTaking people
- Kyungpook National University Chilgok HospitalDaegu, South KoreaTaking people
- Chungnam National University HospitalDaejeon, South KoreaTaking people
- Eulji University HospitalDaejeon, South KoreaTaking people
- Chonnam National University HospitalGwangju, South KoreaTaking people
- Hallym University Medical CenterGyeonggi-do, South KoreaTaking people
- Hanyang University Guri HospitalGyeonggi-do, South KoreaTaking people
- Korea University Ansan HospitalGyeonggi-do, South KoreaTaking people
- Seoul National University Bundang HospitalGyeonggi-do, South KoreaTaking people
- Gachon University Gil Medical CenterIncheon, South KoreaTaking people
- Inha University HospitalIncheon, South KoreaTaking people
- Jeju National University HospitalJeju City, South KoreaTaking people
- jeonbuk National University HospitalJeonju, South KoreaTaking people
- Asan Medical CenterSeoul, South KoreaTaking people
- Ewha Womans University Seoul HospitalSeoul, South KoreaTaking people
- Hanyang University Seoul HospitalSeoul, South KoreaTaking people
- Korea University Guro HospitalSeoul, South KoreaTaking people
- Kyung Hee University HospitalSeoul, South KoreaTaking people
- Kyung Hee University Hospital at GangdongSeoul, South KoreaTaking people
- Samsung Medical CenterSeoul, South KoreaTaking people
- The Catholic University of Korea, Seoul ST. Mary's HospitalSeoul, South KoreaTaking people
- Yonsei University Health System - Gangnam Severance HospitalSeoul, South KoreaNot yet recruiting
- Pusan National University Yangsan HospitalYangsan, South KoreaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Asan Medical Center
- Trial code
- NCT06757764
- Record updated
- 27 March 2026
- Original description
Currently, aspirin plus clopidogrel is considered as a standard acute treatment of ischemic stroke, based on results of CHANCE and POINT trial. However, still a considerable portion of patients showed early stroke recurrence, especially in those with stroke due to large artery atherosclerosis. Cilostazol may have benefit in reducing early stroke recurrence of neurologic deterioriation. The post-hoc analysis of CSPS.com showed that use of cilostazol after 15 days of stroke was effective for preventing subsequent stroke. The effect of adding cilostazol was more effective in those with large artery atherosclerosis and those receiving clopidogrel than aspirin.Read full original descriptionShow less
The Effect and Safety of Therapy Adding Cilostazol in Acute Ischemic Stroke Due to Large Artery Atherosclerosis: CHANGE Trial
Currently, aspirin plus clopidogrel is considered as a standard acute treatment of ischemic stroke, based on results of CHANCE and POINT trial. However, still a considerable portion of patients showed early stroke recurrence, especially in those with stroke due to large artery atherosclerosis. Cilostazol may have benefit in reducing early stroke recurrence of neurologic deterioriation. The post-hoc analysis of CSPS.com showed that use of cilostazol after 15 days of stroke was effective for preventing subsequent stroke. The effect of adding cilostazol was more effective in those with large artery atherosclerosis and those receiving clopidogrel than aspirin.
Inclusion: Age of 20 years or older; Acute ischemic stroke due to large artery atherosclerosis (both including Intra and extracranial atherosclerosis) which may be defined by a ischemic lesion confirmed at diffusion-weighted image and a corresponding significant stenosis (more than 50% of diameter reduction) proximal to the ischemic lesion confirmed by MR angiography or CT angiography; Informed consent obtained within 72h from stroke onset; Acquisition of written informed consent prior to study entry.
Exclusion: Previous mRS higher than 2; Pre-planned for surgery; Combined with acute intracranial haemorrhage; Large infarction unable to start antiplatelet treatment; With initial haemorrhagic transformation; Indicated for anticoagulation; Contraindication for aspirin, clopidogrel or cilostazol; Requirement of long term NSAID; Unable to withdraw consent; Unavailable to participate based on judgement of the investigator; Participants of reproductive potential (PORP)/ Participants of childbearing potential (POCBP) who do not agree to practice methods of birth control or remain fully abstinent from sexual activity with the potential for conception.