Balloon Angioplasty Tested in Minor Unstable Stroke From Narrowed Brain Arteries
Tests balloon angioplasty in adults with minor stroke from narrowed brain arteries.
Plain-language title generated from the registry record
Registry title: Balloon Angioplasty for Minor Unstable Stroke With IntraCranial Atherosclerosis Stenosis (BAMUS-ICAS)
Key facts
- Where
- Shenyang, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a minor ischemic stroke caused by severe narrowing of a brain artery, whose symptoms keep getting worse despite medicine. It tests a balloon procedure to widen the artery.
- Age
- Over 18 years
- Sex
- All sexes can join.
- Disease stage
- Minor ischemic stroke within 1 week of onset (NIHSS 5 or less). Severe narrowing (70-99%) of a brain artery due to hardening of the arteries, or a small branch artery disease with severe narrowing of the main artery. Symptoms have worsened by at least 1 NIHSS point and fluctuate up to the balloon procedure within 24 hours.
- Earlier treatment
- People must already have had the strongest drug treatment (two antiplatelet drugs, combined with a blood thinner), but symptoms still fluctuate or get worse.
- Biomarker or test result
- Narrowing of the brain artery confirmed by MRA, CTA or DSA imaging. Anyone with a past stroke must have an mRS score under 2 points.
Main reasons for not taking part
- Complete blockage of a large brain artery
- Bleeding in the brain in the past 3 months
- Artery narrowing not caused by hardening of the arteries (for example dissection or moyamoya disease)
- Clotting disorder, bleeding tendency or platelets under 100,000
- Pregnant, planning pregnancy or breastfeeding
Read by machine on 12 November 2026.
Where in China
- General Hospital of Northern Theater CommandShenyang, ChinaContact: Zi-Ai ZhaoTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- General Hospital of Shenyang Military Region
- Trial code
- NCT06763458
- Record updated
- 27 April 2026
- Original description
Intracranial atherosclerotic stenosis (ICAS) is a common cause of stroke, especially in East and South Asia, and is significantly associated with stroke recurrence and early neurological deterioration (END) despite aggressive medical management. Minor stroke (National Institutes of Health Stroke, NIHSS score ≤ 5) patients with ICAS often has higher risk of END. The early realization of blood flow patency is closely related to the improvement of patient outcomes. Submaximal balloon angioplasty (SBA) as a safer and simpler intervention which can improve cerebral blood flow. Thus, SBA may be an effective strategy for preventing END in acute ischemic stroke patients with ICAS.Read full original descriptionShow less
Balloon Angioplasty for Minor Unstable Stroke With IntraCranial Atherosclerosis Stenosis (BAMUS-ICAS): a Prospective, Randomized, Multi-center Study
Intracranial atherosclerotic stenosis (ICAS) is a common cause of stroke, especially in East and South Asia, and is significantly associated with stroke recurrence and early neurological deterioration (END) despite aggressive medical management. Minor stroke (National Institutes of Health Stroke, NIHSS score ≤ 5) patients with ICAS often has higher risk of END. The early realization of blood flow patency is closely related to the improvement of patient outcomes. Submaximal balloon angioplasty (SBA) as a safer and simpler intervention which can improve cerebral blood flow. Thus, SBA may be an effective strategy for preventing END in acute ischemic stroke patients with ICAS.
Inclusion: Over 18 years of age; Minor ischemic stroke within 1 week of onset (NIHSS≤5); Have received the best drug treatment (dual antibody, anti-plate combined with anticoagulation), but symptoms still have measurable fluctuations or progression (NIHSS increased by at least 1 point); Symptoms fluctuate to the time of receiving balloon dilation within 24 hours; The etiology was considered to be severe stenosis of the responsible vessels due to intracranial arteriosclerosis (70-99% stenosis), or perforator artery disease with severe stenosis of the carrier artery (confirmed by MRA, CTA or DSA); Patients with first onset or past onset without sequelae such as limb paralysis should not affect the score of this NIHSS, and mRS Score of patients with past onset should be less than 2 points; Patients or family members sign informed consent.
Exclusion: Intracranial hemorrhagic diseases in the past 3 months: cerebral hemorrhage, subarachnoid hemorrhage, etc; Non-atherosclerotic disease-related stenosis: arterial dissection, moya-moya disease, arterioinflammatory disease, etc; Complicated with serious infection or liver, kidney and other serious diseases; Patients with severe inability to control hypertension (systolic blood pressure >200mmHg or diastolic blood pressure >110mmHg); Complicated with other serious diseases, life expectancy < 6 months; Other conditions deemed inappropriate for participation in this study; Clotting disorders or systemic bleeding tendency or platelets less than 100,000; Patients who have developed large intracranial vessel occlusion; Women who are pregnant, have a pregnancy plan or are breastfeeding.