Which comes first: weight-loss surgery or knee replacement for knee osteoarthritis
Compares the order of two operations in adults with obesity and knee osteoarthritis.
Plain-language title generated from the registry record
Registry title: Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First?
Key facts
- Where
- St. John's, CanadaSee the 2 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT06767787, who can take part
Where in Canada
- Health Sciences CentreSt. John's, CanadaNo longer taking part
- St. Clare's Mercy HospitalSt. John's, CanadaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Memorial University of Newfoundland
- Trial code
- NCT06767787
- Record updated
- 30 January 2025
- Original description
The goal of this study is to determine whether undergoing bariatric surgery before knee replacement leads to better outcomes compared to undergoing knee replacement before bariatric surgery. Our secondary goal is to compare complication rates between these groups to determine if there is a difference based on the order of the two procedures.Read full original descriptionShow less
Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First? A Randomized Cross-over Study
The goal of this study is to determine whether undergoing bariatric surgery before knee replacement leads to better outcomes compared to undergoing knee replacement before bariatric surgery. Our secondary goal is to compare complication rates between these groups to determine if there is a difference based on the order of the two procedures.
Participants will be randomly placed in one of two groups, with each undergoing both procedures but in opposite order. Quality of life will be assessed via questionnaires before and between each procedure, and rates of complications will also be documented to compare their rates between groups.
Inclusion: BMI > or = 35, on surgical waitlist for a total knee arthroplasty and laparoscopic sleeve gastrectomy.
Exclusion: a history of revision surgery, surgery for neoplastic disease, significant mental illness, ASA class > 3 denoting absence of significant impact of comorbidities, and previous esophagogastric surgery.