Which comes first: weight-loss surgery or knee replacement for knee osteoarthritis
Compares the order of two operations in adults with obesity and knee osteoarthritis.
Plain-language title generated from the registry record
Registry title: Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First?
Key facts
- Where
- St. John's, CanadaSee the 2 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a high body weight (BMI 35 or more) who are on the waiting list for both a total knee replacement and a sleeve gastrectomy (weight-loss stomach surgery).
- Age
- 18 to 65 years
- Sex
- All sexes can join.
- Disease stage
- BMI of 35 or more, and on the waitlist for a total knee arthroplasty and a laparoscopic sleeve gastrectomy.
- Earlier treatment
- People with a history of revision surgery, surgery for neoplastic disease, or previous esophagogastric surgery cannot join.
Main reasons for not taking part
- History of revision surgery
- Surgery for neoplastic disease
- Significant mental illness
- ASA class above 3
- Previous esophagogastric surgery
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT06767787, who can take part
Where in Canada
- Health Sciences CentreSt. John's, CanadaContact: Daniel G Muller, MD, MHScNo longer taking part
- St. Clare's Mercy HospitalSt. John's, CanadaContact: Jack A Kerr, MDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Memorial University of Newfoundland
- Trial code
- NCT06767787
- Record updated
- 30 January 2025
- Original description
The goal of this study is to determine whether undergoing bariatric surgery before knee replacement leads to better outcomes compared to undergoing knee replacement before bariatric surgery. Our secondary goal is to compare complication rates between these groups to determine if there is a difference based on the order of the two procedures.Read full original descriptionShow less
Morbid Obesity and Severe Knee Osteoarthritis - Which Should Be Treated First? A Randomized Cross-over Study
The goal of this study is to determine whether undergoing bariatric surgery before knee replacement leads to better outcomes compared to undergoing knee replacement before bariatric surgery. Our secondary goal is to compare complication rates between these groups to determine if there is a difference based on the order of the two procedures.
Participants will be randomly placed in one of two groups, with each undergoing both procedures but in opposite order. Quality of life will be assessed via questionnaires before and between each procedure, and rates of complications will also be documented to compare their rates between groups.
Inclusion: BMI > or = 35, on surgical waitlist for a total knee arthroplasty and laparoscopic sleeve gastrectomy.
Exclusion: a history of revision surgery, surgery for neoplastic disease, significant mental illness, ASA class > 3 denoting absence of significant impact of comorbidities, and previous esophagogastric surgery.