Anesthetic Gas Desflurane and Memory Changes After Surgery in Older Adults
Studies whether desflurane anesthesia may affect thinking after surgery in people aged 70 or older.
Plain-language title generated from the registry record
Registry title: Desflurane Potentially Induces Postoperative Cognitive Dysfunction in Elderly Patients Undergoing Perioperative Procedures by Modulating Cdc42 and Clock Proteins
Key facts
- Where
- Baotou, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people over 70 who will have planned surgery under general anesthesia with desflurane. It studies memory and thinking changes after surgery.
- Age
- Over 70 years
- Sex
- All sexes
- Disease stage
- General health rated ASA I-III before planned surgery that needs general anesthesia with desflurane.
Main reasons for not taking part
- Dementia or another brain disease that affects thinking
- Memory and thinking test (MoCA) score below 20 before surgery
- Severe mental illness such as psychosis, severe depression or bipolar disorder
- Stroke, TIA or another significant nerve or brain disorder
- Severe liver or kidney problems
Read by machine on 12 November 2026.
Where in China
- Inner Mongolia Baogang HospitalBaotou, ChinaContact: Xiaguang Wang, Master's degreeNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Xiaguang Duan
- Trial code
- NCT06772558
- Record updated
- 14 January 2025
- Original description
This clinical trial investigates whether desflurane induces postoperative cognitive dysfunction (POCD) in elderly patients undergoing perioperative procedures by modulating Cdc42 and Clock proteins. The primary research questions are: (1) Does desflurane administration contribute to POCD in this patient population? and (2) Are alterations in Cdc42 and Clock protein levels associated with desflurane-induced POCD in elderly patients? To address these questions, elderly patients will be administered desflurane for anesthesia maintenance. Postoperative assessments will then compare blood levels of Cdc42 and Clock proteins, and examine related signaling pathways, between a control group and a POCD group.Read full original descriptionShow less
The Potential Mechanism by Which Desflurane Induces Postoperative Cognitive Dysfunction in Elderly Perioperative Patients Involves the Modulation of Cdc42 and Clock Proteins, and Their Related Signaling Pathways.
This clinical trial investigates whether desflurane induces postoperative cognitive dysfunction (POCD) in elderly patients undergoing perioperative procedures by modulating Cdc42 and Clock proteins. The primary research questions are: (1) Does desflurane administration contribute to POCD in this patient population? and (2) Are alterations in Cdc42 and Clock protein levels associated with desflurane-induced POCD in elderly patients? To address these questions, elderly patients will be administered desflurane for anesthesia maintenance. Postoperative assessments will then compare blood levels of Cdc42 and Clock proteins, and examine related signaling pathways, between a control group and a POCD group.
Study participants will receive desflurane anesthesia maintained at a Bispectral Index (BIS) value of 40-60. Postoperative cognitive function will be assessed on the second day using the Montreal Cognitive Assessment (MoCA), and participants will be categorized into either a control group or a POCD group based on MoCA performance. Cognitive function and blood levels of Cdc42 and Clock proteins will be recorded. Furthermore, the study will also investigate associated signaling pathways.
Inclusion: Age > 70 years; American Society of Anesthesiologists (ASA) physical status classification I-III; Scheduled to undergo elective surgery requiring general anesthesia with desflurane; Able and willing to provide voluntary written informed consent; Able to understand the study procedures and complete follow-up assessments.
Exclusion: Pre-existing diagnosis of dementia or any other neurodegenerative disease that could affect cognitive function; History of severe psychiatric disorders, including psychosis, severe depression, or bipolar disorder; Unstable angina, uncontrolled hypertension, or a history of myocardial infarction within the past 6 months; Severe chronic obstructive pulmonary disease (COPD) with significant respiratory compromise, or other significant respiratory disease; History of stroke, transient ischemic attack (TIA), or other significant neurological disorders; History of alcohol or drug abuse; Known allergy or contraindication to any of the study drugs; Other conditions at the discretion of the investigator that could interfere with the conduct of the study or the interpretation of the results; Severe hepatic or renal impairment, defined as Child-Pugh class C for liver disease, or glomerular filtration rate (GFR) < 30 mL/min/1.73 m2 for kidney disease; Preoperative Montreal Cognitive Assessment (MoCA) score < 20; Patients with visual, auditory, or language impairments that would interfere with cognitive testing.