Cognitive Reappraisal Training for Borderline Personality (BPD)
Key facts
- Who runs it
- Icahn School of Medicine at Mount Sinai
- Where
- New York, United StatesSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 130 people, planned
- Started
- 15 Nov 2024
- Expected to end
- 31 Jul 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Cognitive Reappraisal by Distancing
- Downregulate condition
- Record updated
- 9 September 2026
Who can take part
- Age
- 18 years to 55 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 12 criteriaShow less
Who can take part
- Medically healthy men and women with Borderline Personality Disorder who are mentally competent and give informed voluntary written consent
- Participants will be between the ages of 18 and 55
- Within these requirements, the inclusion and exclusion criteria do not reflect participation based on gender or racial/ethnic group. The targeted/planned enrollment is a reflection of previous recruitment of female and ethnic minorities in other studies conducted by the PI and their colleagues and includes representations of both genders and all minorities
- Participants with comorbid avoidant personality disorder will be included
- Participants who meet criteria for PTSD will be included as long as they are not actively experiencing symptoms
Who cannot take part
- BPD participants will not meet DSM-5 criteria for present PTSD, bipolar I disorder, schizophrenia, schizoaffective disorder, substance use disorder within the past 6 months, organic mental syndromes, head trauma, schizotypal personality disorder, avoidant personality disorder, CNS neurological disease, or seizure disorder. Participants meeting criteria for a non-IV substance use disorder more than 6 months prior to enrollment will not be excluded. This study allows patients who are currently taking psychotropic medications or are in psychotherapy, so long as there has been no change in medication or psychotherapy over the preceding two months
- Participants may not have a pacemaker, surgical clips, any metallic implants, or shrapnel fragments that would contraindicate MRI scanning
- Participants will not meet criteria for Schizotypal Personality Disorder
- Participants currently meeting criteria for Major Depressive Disorder will be excluded
- Participants currently meeting criteria for major depressive disorder
- Participants meeting criteria for substance use disorder within the last 6 months or of an IV-substance use disorder at any time
- Pregnant women
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 55 years old?
Where in United States
- Icahn School of Medicine at Mount SinaiNew York, United StatesContact: Harold W Koenigsberg (principal investigator)Taking people
About the trial
What the trial wants to find out
Previous work by the group convinced the researchers to pursue development of focused cognitive reappraisal training as a novel approach to treatment of BPD, either as stand-alone treatment or in concert with evidence-based treatments of BPD. The present proposal aims to refine and test a proposed clinical intervention for BPD patients, training in reappraisal-by-distancing, in terms of its ability to influence hypothesized neural and behavioral targets and, once that is established, to demonstrate its ability improve clinically relevant outcome measures.
The 2 groups in the trial
- Cognitive Reappraisal-by-Distancing (CRD)Treatment being tested
Patients will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures.
Treatment: Cognitive Reappraisal by Distancing
- Downregulate Condition (CD)Existing treatment, for comparison
Patients will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.
Treatment: Downregulate condition
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Cognitive Reappraisal Training Targeting Emotion Circuits As a Therapeutic Intervention in Borderline Patients
- Fit questions
- Built from NCT06772831, who can take part
- Record updated
- 9 September 2026