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Taking people in United StatesNo phase

Cognitive Reappraisal Training for Borderline Personality (BPD)

Key facts

Who runs it
Icahn School of Medicine at Mount Sinai
Where
New York, United StatesSee the site
Trial code
Status
Recruiting
People taking part
130 people, planned
Started
15 Nov 2024
Expected to end
31 Jul 2027
Type of study
Interventional, 2 groupsOne group gets an existing treatment, for comparison.
Treatments tested
  • Cognitive Reappraisal by Distancing
  • Downregulate condition
Record updated
9 September 2026

Who can take part

Age
18 years to 55 years
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 12 criteriaShow less

Who can take part

  • Medically healthy men and women with Borderline Personality Disorder who are mentally competent and give informed voluntary written consent
  • Participants will be between the ages of 18 and 55
  • Within these requirements, the inclusion and exclusion criteria do not reflect participation based on gender or racial/ethnic group. The targeted/planned enrollment is a reflection of previous recruitment of female and ethnic minorities in other studies conducted by the PI and their colleagues and includes representations of both genders and all minorities
  • Participants with comorbid avoidant personality disorder will be included
  • Participants who meet criteria for PTSD will be included as long as they are not actively experiencing symptoms

Who cannot take part

  • BPD participants will not meet DSM-5 criteria for present PTSD, bipolar I disorder, schizophrenia, schizoaffective disorder, substance use disorder within the past 6 months, organic mental syndromes, head trauma, schizotypal personality disorder, avoidant personality disorder, CNS neurological disease, or seizure disorder. Participants meeting criteria for a non-IV substance use disorder more than 6 months prior to enrollment will not be excluded. This study allows patients who are currently taking psychotropic medications or are in psychotherapy, so long as there has been no change in medication or psychotherapy over the preceding two months
  • Participants may not have a pacemaker, surgical clips, any metallic implants, or shrapnel fragments that would contraindicate MRI scanning
  • Participants will not meet criteria for Schizotypal Personality Disorder
  • Participants currently meeting criteria for Major Depressive Disorder will be excluded
  • Participants currently meeting criteria for major depressive disorder
  • Participants meeting criteria for substance use disorder within the last 6 months or of an IV-substance use disorder at any time
  • Pregnant women

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 55 years old?

Where in United States

  • Icahn School of Medicine at Mount SinaiNew York, United StatesContact: Harold W Koenigsberg (principal investigator)Taking people

About the trial

What the trial wants to find out

Previous work by the group convinced the researchers to pursue development of focused cognitive reappraisal training as a novel approach to treatment of BPD, either as stand-alone treatment or in concert with evidence-based treatments of BPD. The present proposal aims to refine and test a proposed clinical intervention for BPD patients, training in reappraisal-by-distancing, in terms of its ability to influence hypothesized neural and behavioral targets and, once that is established, to demonstrate its ability improve clinically relevant outcome measures.

The 2 groups in the trial

  • Cognitive Reappraisal-by-Distancing (CRD)Treatment being tested

    Patients will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures.

    Treatment: Cognitive Reappraisal by Distancing

  • Downregulate Condition (CD)Existing treatment, for comparison

    Patients will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks.

    Treatment: Downregulate condition

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Cognitive Reappraisal Training Targeting Emotion Circuits As a Therapeutic Intervention in Borderline Patients
Fit questions
Built from NCT06772831, who can take part
Record updated
9 September 2026