Compares two treatments for ovarian endometrioma cysts in women
Compares sclerotherapy with surgical removal for endometrioma in adults 18 to 45.
Key facts
- Who runs it
- Chelsea and Westminster NHS Foundation Trust
- Where
- London, United KingdomSee the site
- Trial code
- Registry title
- Endometrioma Sclerotherapy and Ovarian Preservation
- Status
- Recruiting
- People taking part
- 60 people, planned
- Started
- 21 Feb 2025
- Expected to end
- 31 Dec 2027
- Type of study
- Interventional, 2 groups
- Treatments tested
- Sclerotherapy
- Routine Care
- Record updated
- 25 November 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for women with an ovarian endometrioma of 2cm (0.8 in) or more who are due to have laparoscopic surgery. It compares ethanol sclerotherapy with surgical removal.
- Age
- Age 18-40 in the inclusion criteria (the registry lists 18 to 45 years).
- Sex
- Female only (XX genotype, assigned female at birth).
- Disease stage
- Suspected endometrioma on one or both ovaries, 2cm (0.8 in) or more on ultrasound (TVUSS) and/or pelvic MRI. Due to be listed for laparoscopic surgery: pain from endometriosis where medicines have not worked or are not acceptable, or to help assisted reproduction (ART).
Main reasons for not taking part
- Postmenopausal
- Suspected cancer (malignancy)
- Cannot have a transvaginal ultrasound (TVUSS)
- Cannot understand verbal or written information in English
- Lacks capacity to consent when recruited
The registry criteria, word for word
Show all 11 criteriaShow less
Who can take part
- Female (XX genotype, assigned female at birth)
- Age 18-40
- Finding of suspected uni- or bi-lateral ovarian endometrioma(ta) of ≥ 2cm on TVUSS and/or pelvic MRI scan (TVUSS, a uni- or multi-locular ovarian cystic lesion with low level echoes and diffuse homogeneous ground glass appearance; MRI any of, ovarian lesion hyperintense T1 without loss of signal on T1 fat-suppressed images, hypointense T2 exhibiting shading sign and/or T2 dark spot sign, variable restricted diffusion on DWI)
- Appropriate to be listed for laparoscopic excision of endometrioma (Endometrioma ≥2cm, pain symptoms attributable to endometriosis where medical management is unsuccessful or unacceptable to the patient, to facilitate ART)
Who cannot take part
- Suspicion of malignancy
- Postmenopausal status
- Unable to undergo TVUSS
- Declines to take part in the study
- Unable to understand verbal or written information in English
- Lack of capacity to consent at the point of recruitment
- Known safeguarding issues
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Where in United Kingdom
- Chelsea and Westminster NHS Foundation TrustLondon, United KingdomContact: Gulsah CetinkayaTaking people
About the trial
What the trial wants to find out
A randomised controlled trial assessing ovarian reserve after laparoscopic ethanol sclerotherapy of ovarian endometrioma compared to standard treatment of surgical excision of endometrioma.
Read full original descriptionShow less
Secondary outcomes will include endometrioma recurrence, symptomatology and inflammatory environment.
The 2 groups in the trial
- Surgical Management of EndometriomaOther group
Routine Care
Treatment: Routine Care
- Laparoscopic SclerotherapyTreatment being tested
Laparoscopic ethanol sclerotherapy of endometrioma
Treatment: Sclerotherapy
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Endometrioma Sclerotherapy and Ovarian Preservation: a Randomised Control Trial of Laparoscopic Sclerotherapy vs Traditional Excision of Endometrioma
- Plain-language title
- Compares two treatments for ovarian endometrioma cysts in womenGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT06775769, who can take part
- Record updated
- 25 November 2025