Tests a tiny brain recording probe during deep brain stimulation surgery in Parkinson disease
Tests a tiny brain recording probe in awake people with Parkinson disease.
Plain-language title generated from the registry record
Registry title: Neocortical Microarchitecture of Executive Function
Key facts
- Where
- Aurora, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 45 and 85 years old?
Source: NCT06778135, who can take part
Where in United States
- University of ColoradoAurora, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Colorado, Denver
- Trial code
- NCT06778135
- Record updated
- 5 November 2026
- Original description
This study is being done to the determine the ability and utility of using the Neuropixels probes in the human brain. A Neuropixels probe will be inserted into and removed from the brain of awake human patients who are undergoing awake Deep Brain Stimulation (DBS) surgery.Read full original descriptionShow less
Neocortical Microarchitecture of Executive Function Using Large-scale Intracranial Electrophysiology
This study is being done to the determine the ability and utility of using the Neuropixels probes in the human brain. A Neuropixels probe will be inserted into and removed from the brain of awake human patients who are undergoing awake Deep Brain Stimulation (DBS) surgery.
Inclusion: Diagnosis of Parkinson's disease and refractory to medications requiring deep brain stimulation; Aged 45-85; Able to provide informed consent; Normal neuropsychiatric evaluation that includes tests of executive function demonstrating no greater than mild impairments, within expectation for Parkinson's disease; Medically able to undergo deep brain stimulation surgery as evaluated by study neurosurgeon; Surgical plan includes an entry point that can safely be placed in the dorsal lateral PFC; Able to tolerate awake deep brain stimulation surgery with a plan for the case to be done awake; Able to tolerate 25 additional minutes of awake surgery; Able to participate and comply with tasks adequately, including instructions provided in English.
Exclusion: Inability to tolerate awake surgery as determined by the treating neurologist and study neurosurgeon; Moderate, or severe cognitive impairment as determined by a licensed neuropsychologist during routine neuropsychological evaluation; Moderate or severe cognitive impairment or executive function deficits as determined by neuropsychological testing; Inability to safely access the dorsal lateral prefrontal cortex for an entry location; Evidence of a clinically significant abnormality on preoperative imaging.