Studies hepatitis B virus gene changes and drug resistance in chronic hepatitis B
Studies virus gene changes and drug resistance in adults with chronic hepatitis B.
Plain-language title generated from the registry record
Registry title: Molecular Characteristics of Hepatitis B Virus Integration, Mutation, and Drug Resistance
Key facts
- Where
- Beijing, ChinaSee the site
Where in China
- Beijing Friendship HospitalBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Beijing Friendship Hospital
- Trial code
- NCT06779864
- Record updated
- 17 January 2025
- Original description
Patients with a confirmed diagnosis of chronic hepatitis B (CHB) who have complete clinical data and retained blood or liver tissue samples will be enrolled. All patients will be grouped based on cohort sources: the Antiviral Treatment Cohort and the Cross-Sectional Epidemiological Survey Cohort.Read full original descriptionShow less
Molecular Characteristics of Hepatitis B Virus Integration, Mutation, and Drug Resistance
Patients with a confirmed diagnosis of chronic hepatitis B (CHB) who have complete clinical data and retained blood or liver tissue samples will be enrolled. All patients will be grouped based on cohort sources: the Antiviral Treatment Cohort and the Cross-Sectional Epidemiological Survey Cohort.
Patients in the Antiviral Treatment Cohort have received antiviral treatment and are followed every six months. During follow-up, HBV-related endpoint events, including cirrhosis decompensations (such as ascites, esophageal variceal bleeding, and hepatic encephalopathy), hepatocellular carcinoma (HCC), liver transplantation, and liver-related death, will be collected.
In the Cross-Sectional Epidemiological Survey Cohort, clinical data will be collected at a single time point, with some patients not receiving antiviral treatment.
In both cohorts, retained blood and liver tissue samples will be used to further analyze HBV genotypes, viral integration, drug resistance, and the molecular characteristics of mutations.
Finally, a detailed description will be provided regarding the correlation between these HBV genetic molecular features and demographic distribution, clinical phases, and various clinical outcome events.
Inclusion: Patients with hepatitis B surface antigen positive; Patients who have complete demographic information, clinical data and retained blood samples or liver tissue samples.
Exclusion: Subject who without blood samples or liver tissue samples.