Testing light therapy with CPAP in people with depression and sleep apnea
Tests light therapy alongside CPAP use in adults with depression and sleep apnea.
Key facts
- Who runs it
- Hôpital le Vinatier
- Where
- Bron, FranceSee the site
- Trial code
- Registry title
- Combining Light Therapy and CPAP in Depression
- Status
- Recruiting
- People taking part
- 130 people, planned
- Started
- 17 Jan 2025
- Expected to end
- 30 Oct 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Light therapy
- Record updated
- 29 April 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with major depression and obstructive sleep apnea who need a CPAP machine. It tests whether two weeks of light therapy helps people keep using the CPAP.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- A major depressive episode (DSM-V) with a MADRS score of 15 or more, and obstructive sleep apnea shown on a sleep test (AASM 2017 criteria) that needs CPAP.
Main reasons for not taking part
- Pregnant or breast-feeding women
- Unstable psychiatric or physical illness that the investigators see as not fitting the study
- Eye conditions that rule out light therapy, such as retinopathy, glaucoma or eye surgery in the last 3 months
- Nasal obstruction
- Refusing actimetry, light therapy or CPAP
The registry criteria, word for word
Show all 12 criteriaShow less
Who can take part
- Adults consulting at the MICHEL JOUVET unit, CH Le Vinatier, Bron
- Adults with a diagnosis of major depressive episode (DSM-V) and with a MADRS score ≥ 15
- Adults with a diagnosis of OSAS on ventilatory polygraphy or polysomnography (AASM 2017 criteria) requiring CPAP
Who cannot take part
- Contraindication to light therapy: retinopathy, retinitis pigmentosa, diabetic retinopathy, macular degeneration, glaucoma, recent eye surgery (less than 3 months); patient wishing to choose a provider other than the protocol provider
- Refusal to use actimetry, refusal to use light therapy, refusal to use CPAP
- Unstable psychiatric or physical pathology (e.g., hypomania, high suicidal risk) considered incompatible with the study by the investigators
- Other psychiatric, neurologic or somatic conditions
- Refusal to participate
- Pregnant and breast-feeding women
- Under guardianship or curatorship
- Patient wishing to choose a device other than SEFAM's S-BOX or a mask other than the nasal mask at the time of introduction
- Nasal obstruction
Where in France
- Centre Hospitalier Le VinatierBron, FranceContact: Sébastien S CATOIRE, DrTaking people
About the trial
What the trial wants to find out
In a double-blind, parallel-group controlled trial, we aim to measure the effect of two weeks of light therapy combined with the CPAP on compliance CPAP in patients with major depressive disorder.
The 2 groups in the trial
- Active Light therapyExisting treatment, for comparison
Active light therapy comes in the form of glasses and emits an intensity of 1200 Lux and a cyan-colored light spectrum (500nm), corresponding to a retinal exposure of 361.91uW/cm2 with a 30-min daily exposure upon waking for 2 weeks
Treatment: Light therapy
- Sham Light therapyPlacebo, for comparison
Sham light therapy is the same device but in an attenuated version (addition of a filter and reduction of light intensity), emitting an intensity of 33 Lux and a light spectrum (600 nm) with a 30-min daily exposure upon waking for 2 weeks.
Treatment: Light therapy
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Effects of Light Therapy on Compliance With Continuous Positive Airway Pressure in a Population of Depressed Patients Newly Fitted With Devices for Obstructive Sleep Apnea
- Plain-language title
- Testing light therapy with CPAP in people with depression and sleep apneaGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Publications
- Record updated
- 29 April 2025