Effect of RNS in Treatment-refractory Tourette's Syndrome
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Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT06785532, who can take part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Xuanwu Hospital, Beijing
- Trial code
- NCT06785532
- Record updated
- 21 January 2025
- Original description
The study is to investigate the effect of personalized responsive neurostimulation (RNS) therapy guided by stereoelectroencephalography (SEEG) in patients with treatment-resistant Tourette's Syndrome (TR-TS).Read full original descriptionShow less
Investigating the Effect of Responsive Neurostimulation (RNS) in Patients with Treatment-refractory Tourette's Syndrome (TR-TS)
The study is to investigate the effect of personalized responsive neurostimulation (RNS) therapy guided by stereoelectroencephalography (SEEG) in patients with treatment-resistant Tourette's Syndrome (TR-TS).
Inclusion: aged 18-65; able to provide written informed consent; have a diagnosis of Tourette's syndrome according to the Statistical Manual of Mental Disorders-Fourth Edition-Text Revised (DSM-IV-TR) criteria and confirmed by the Mini-International Neuropsychiatric Interview Chinese version 5.0; with a YGTSS of at least 35 for at least 12 months before surgery, while YGTSS- Total Motor≥15; must have failed conventional medical treatment at adequate therapeutic doses of three classes of medication lasting for at least three months; must not be suitable for behavioural intervention or that this intervention is inappropriate or unsuccessful; have been on stable comorbid conditions without suicidal ideation for at least six months.
Exclusion: have a treatment history that includes electroconvulsive therapy (ECT), modified electroconvulsive therapy (MECT), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), DBS, and transcranial magnetic stimulation (TMS); have been involved in other clinical studies within three months before enrollment in this study; presence of other psychotic disorders; with a history of traumatic brain injury (TBI); unstable neurological or coagulation disorders; any conditions considered by the study group; presents a suicide risk (defined as a HAMD-17 score of ≥3 on suicide-related items); experience difficulty in effectively communicating with investigators; with intracranial or cardiovascular stents; substance abuse within the past six months; women who are pregnant, lactating, or of childbearing potential who refuse the use of reliable contraception during the study.