Efficacy of Esketamine for Patients With Irritable Bowel Syndrome
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Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT06788444, who can take part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Beijing Tiantan Hospital
- Trial code
- NCT06788444
- Record updated
- 28 August 2026
- Original description
To explore the efficacy of a single low dose of esketamine for patients with irritable bowel syndrome (IBS).Read full original descriptionShow less
Efficacy of a Single Low Dose of Esketamine for Patients With Irritable Bowel Syndrome: Study Protocol for a Randomised Controlled Trial
To explore the efficacy of a single low dose of esketamine for patients with irritable bowel syndrome (IBS).
Inclusion: Age of 18 - 60 years; American Society of Anesthesiologists (ASA) physical status of I - II; Body Mass Index (BMI) of 15 - 30; Scheduled for colonoscopy; Positive screening results according to the Rome IV diagnostic criteria for IBS; Patients who met Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for Anxiety disorder (ANXD) and/or major depressive disorder (MDD) .
Exclusion: A previous diagnosis of colon cancer, infammatory bowel disease or coeliac disease; GastrointestinalTract (GI) bleeding; A history of weight loss (at least 10%) within six months; A history of abdominal surgery (other than hernia repair or appendectomy); Mental disorder patients with severe personality disorder, active suicidal ideation and history of self-harm within 1 year; Allergy or any contraindications to the drugs used in the study, such as severe cardiovascular disease, refractory hypertension, or hyperthyroidism; Any organic lesions confirmed by clinical examination, laboratory examination or colonoscopy；; Patients older than 55 years of age who have not undergone a colonoscopy in the past 5 years；; Participate in other clinical trials within 3 months; Drinking more than 50 units (1 unit refers to 10ml of pure alcohol) per week; Pregnancy or breastfeeding.