Tests a minimally invasive bypass surgery for narrowed heart arteries
Tests a smaller-incision bypass operation in adults with blocked heart arteries.
Plain-language title generated from the registry record
Registry title: Minimally Invasive Coronary Artery Bypass Surgery in Patients With Multi Vessel Coronary Disease
Key facts
- Where
- São Paulo, BrazilSee the site
Where in Brazil
- INCOR - Heart Institute from the University of Sao PauloSão Paulo, BrazilNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Sao Paulo General Hospital
- Trial code
- NCT06794359
- Record updated
- 4 May 2026
- Original description
The objective of this study is to evaluate the safety and feasibility of Minimally Invasive Coronary Artery Bypass surgery in selected patients ,with multi vessel coronary disease.Read full original descriptionShow less
Minimally Invasive Coronary Artery Bypass Surgery: Prospective and Randomized Study to Validate the Minimally Invasive Approach Through Left Anterior Mini Thoracotomy in Patients With Milti Vessel Coronary Disease
The objective of this study is to evaluate the safety and feasibility of Minimally Invasive Coronary Artery Bypass surgery in selected patients ,with multi vessel coronary disease.
This trial is designed to be a pilot study that will gather comparative information on the clinical performance of the minimally invasive treatment, evaluated by the composite measure of all-cause death, myocardial infarction, stroke, or unplanned repeat revascularization - in hospital, 30-day and 6 months.
Inclusion: Patients 18-years-old or older; Isolated myocardial revascularization procedure; Double or Triple-vessel disease with proximal or mid LAD disease with angiographic diameter stenosis \> 70% by visual analysis in all territories, requiring myocardial revascularization OR proximal LAD disease with angiographic diameter stenosis 50-70% by visual analysis in any territory but with invasive or non-invasive evidence of flow-limiting stenosis in all three territories, requiring myocardial revascularization; Total SYNTAX score \> 22 or low Syntax score unsuitable for PCI; Clinical and anatomic eligibility for both Minimally invasive and Conventional CABG surgery as agreed to by surgical team; Silent ischemia, stable angina, unstable angina or recent MI; If recent MI, cardiac biomarkers must have returned to normal prior to randomization; Ability to sign informed consent and comply with all study procedures.
Exclusion: Need for any concomitant cardiac surgery other than CABG (e.g. valve surgery, aortic repair, etc.), or intent that if the patient randomizes to surgery, any cardiac surgical procedure other than isolated CABG will be performed; Emergency surgery; Chronic Pulmonary obstructive disease; Renal failure disease; Peripheral vascular disease; Non cardiac co-morbidities with life expectancy less than 1 year; Reoperation; Left ventricle disfunction (EF\<40%); Obesity; Sternum anatomic defects including pectus excavatum; Ascending aorta severe calcification.