Following women with cystic fibrosis through pregnancy and their babies' early health
Studies women with cystic fibrosis during pregnancy and early parenthood, plus their infants.
Plain-language title generated from the registry record
Registry title: A Study of Females With CF Throughout Pregnancy and Post-partum, and Follow up of Their Offspring
Key facts
- Where
- London, United KingdomSee the site
Where in United Kingdom
- Royal Brompton HospitalLondon, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Royal Brompton & Harefield NHS Foundation Trust
- Trial code
- NCT06797206
- Record updated
- 1 October 2025
- Original description
In this study, investigators aim to study in detail the physical (including nutritional and pulmonary) and mental health of females with cystic fibrosis (CF) planning a pregnancy, during pregnancy, and in the early parenthood period.Read full original descriptionShow less
An Observational Study to Evaluate the Impact of Pregnancy and Parenthood in Females With Cystic Fibrosis and Their Offspring in the CFTR Modulator Era.
In this study, investigators aim to study in detail the physical (including nutritional and pulmonary) and mental health of females with cystic fibrosis (CF) planning a pregnancy, during pregnancy, and in the early parenthood period.
Additionally the health of offspring in infancy and early life will be studied to understand if further screening investigations or clinical care models should be part of clinical guidelines
Inclusion: 'Mama' sub-study:; Written informed consent obtained from participant; Under the care of Royal Brompton Hospital CF Reproductive and Maternal Health Service; Age 16 years or above at time of recruitment; Confirmed diagnosis of CF; Planning a pregnancy or pregnant at time of recruitment; Ability to adhere to the required visits and investigations; 'Mini' sub-study:; Written informed consent obtained from participant's legal guardian; Infants who have one biological parent with a confirmed diagnosis of CF under care of Royal Brompton Hospital Adult CF Service; Less than 12 months of age at first visit; Ability to adhere to the required visits and investigations; 'Midi' sub-study:; Written informed consent obtained from participant's legal guardian; Children who have one biological parent with a confirmed diagnosis of CF who is under the care of Royal Brompton Hospital Adult CF Service; Age three to six years at time of visit; Ability to adhere to the required visits and investigations.
Exclusion: Any significant health condition which would cause inability to comply with protocol based on investigator discretion; History of lung transplantation; 'Mini' sub-study:; A significant health condition which is known to affect lung function or imaging based on investigator discretion; 'Mama' sub-study:; Legal guardians' inability to provide consent to participate in the study; Mother of infant has significant comorbidities unrelated to CF which could affect infant outcomes based on investigator discretion; 'Midi' sub-study:; Legal guardians' inability to provide consent to participate in the study.