Following adults with obesity who have no metabolic disease
Studies which factors lead people with healthy obesity to develop metabolic disease over time.
Plain-language title generated from the registry record
Registry title: Natural Course of Initially Metabolic Healthy Obese Individuals (Healthy Obesity)?
Key facts
- Where
- Baden, SwitzerlandSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 60 years old?
Source: NCT06799897, who can take part
Where in Switzerland
- dTIP / ETH ZürichBaden, SwitzerlandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- ETH Zurich
- Trial code
- NCT06799897
- Record updated
- 30 May 2025
- Original description
The main goal of this study is to gain a thorough understanding, which specific factors drive the unhealthy sequelae of obesity. Therefore, the investigators want to understand:Read full original descriptionShow less
Natural Course of Initially Metabolic Healthy Obese Individuals (Healthy Obesity)?
The main goal of this study is to gain a thorough understanding, which specific factors drive the unhealthy sequelae of obesity. Therefore, the investigators want to understand:
1. What distinguishes obese persons without metabolic diseases from those with medical diseases in a cross-sectional comparison? 2. Which factors drive the conversions from metabolically healthy obesity into a metabolically unhealthy obesity in a longitudinal approach?
Inclusion: Signed Informed Consent Form; Age between 18 and 60 years; BMI 30-50 kg/m2; Knowledge of German, which requires sufficient written and allow oral patient education; Blood pressure < 140/90 mmHg; Normal glucose metabolism; HbA1c < 6.5 %; Fasting Glucose < 7.0 mmol/l; Normal lipid metabolism; o LDL-cholesterol < 5.0 mmol/l; ≤ 2 of the following metabolic syndrome criteria combined (excluding waist circumference); TG > 1.7 mmol/l; HDL-cholesterol > 1.0 mmol/l (male) / > 1.3 mmol/l (female); Fasting glucose ≥ 5.6 mmol/l; BP ≥ 130/85 mmHg.
Exclusion: Medication and / or pathologies that prevent a safe execution of the fat tissue biopsies; History of or planned bariatric operation; Medical conditions that prevent examinations and testing (e.g. symptomatic cardiovascular diseases); Active Malignant tumor (<2a remission); Pregnancy.