Proton beam radiotherapy for children with abdominal neuroblastoma
Studies proton beam radiotherapy in children with abdominal neuroblastoma.
Plain-language title generated from the registry record
Registry title: Pencil Beam Scanning Proton Beam Radiotherapy for the Management of Abdominal Neuroblastoma
Key facts
- Where
- London and Manchester, United KingdomSee the 2 sites
Where in United Kingdom
- University College London Hospitals NHS Foundation TrustLondon, United KingdomTaking people
- The Christie NHS Foundation TrustManchester, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- The Christie NHS Foundation Trust
- Trial code
- NCT06804447
- Record updated
- 10 November 2026
- Original description
Proton Beam Therapy (PBT) and Evaluative Commissioning in Protons (ECIP):Read full original descriptionShow less
Pencil Beam Scanning Proton Beam Radiotherapy for the Management of Abdominal Neuroblastoma - An Evaluative Commissioning in Protons (ECIP) Study
Proton Beam Therapy (PBT) and Evaluative Commissioning in Protons (ECIP):
PBT is an advanced radiotherapy technique. There are two National Health Service (NHS) PBT treatment centres in the United Kingdom, in Manchester and London. The NHS is committed to ensuring the best use of this limited resource by investigating which patients will benefit from PBT. ECIP is a programme of studies exploring the role of PBT in different types of cancer funded by NHS England. ECIP studies are not randomised, eligible patients will be offered PBT. Any eligible UK patient can be referred, and accommodation is available for patients who don't live close to a PBT centre. The main benefit of PBT, compared with standard photon radiotherapy, is predicted reduction in radiation dose to surrounding healthy tissues. With photon radiotherapy, some radiation passes beyond the target area, affecting healthy tissues and causing side-effects. With PBT, the radiation dose stops within the target area, causing less damage to surrounding tissues, and limiting side effects.
SUPERMAN:
SUPERMAN is a study within the ECIP programme. It is sometimes not entirely clear whether PBT or photon radiotherapy is better for the treatment of a patient with abdominal neuroblastoma. The aim of SUPERMAN is to choose the best radiotherapy technique and to better understand how to monitor and adapt PBT for these patients.
Inclusion: Any patient with histologically confirmed abdominal or abdominal-pelvic neuroblastoma who are eligible and fit for radical radiotherapy; Written informed consent from patient, parent or guardian - this includes consent for the minimum baseline, treatment and follow up assessments; and for their data to be stored and used for research, within the appropriate Proton Clinical Outcomes Units and NHS Proton Registry; Patients registered female at birth of childbearing potential agree to use effective contraception between the planning Computed Tomography (CT) scan and the end of treatment.
Exclusion: Pregnant patient.