Heart Recovery After Surgery for Leaky Aortic Valve and Mitral Leakage
Observes heart recovery after valve surgery in adults with enlarged heart chambers.
Plain-language title generated from the registry record
Registry title: Left Ventricular Reverse Remodeling Evaluation After Surgical Correction of Aortic Regurgitation
Key facts
- Where
- Moscow and Voronezh, RussiaSee the 2 sites
Where in Russia
- Petrovsky National Research Center of SurgeryMoscow, RussiaTaking people
- Voronezh Regional Clinical Hospital No. 1Voronezh, RussiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Petrovsky National Research Centre of Surgery
- Trial code
- NCT06805253
- Record updated
- 11 June 2025
- Original description
Investigators assume that surgical correction approach to functional mitral regurgitation during intervention for chronic aortic regurgitation in patients with severe enlargement of the left heart chambers influences reverse remodeling of the left ventricle (LV) in the postoperative period. It is suggested that functional mitral regurgitation (MR) provides supra-physiological left ventricle volume overload and this fact plays positive role in early-stage post-operative left ventricle volume and function recovery. LV volume, systolic and diastolic function will be monitored with echocardiography (EchoCG) along with life quality in patients with different grades of functional mitral regurgitation secondary to severe chronic aortic insufficiency after surgical treatment of aortic regurgitation.Read full original descriptionShow less
Left Ventricular Reverse Remodeling Outcomes Evaluation in Patients With Aortic Regurgitation After Surgical Treatment
Investigators assume that surgical correction approach to functional mitral regurgitation during intervention for chronic aortic regurgitation in patients with severe enlargement of the left heart chambers influences reverse remodeling of the left ventricle (LV) in the postoperative period. It is suggested that functional mitral regurgitation (MR) provides supra-physiological left ventricle volume overload and this fact plays positive role in early-stage post-operative left ventricle volume and function recovery. LV volume, systolic and diastolic function will be monitored with echocardiography (EchoCG) along with life quality in patients with different grades of functional mitral regurgitation secondary to severe chronic aortic insufficiency after surgical treatment of aortic regurgitation.
Inclusion: Age over 18 years; Planned primary elective surgery for chronic aortic regurgitation; Presence of functional mitral regurgitation; End-diastolic volume of the left ventricle \>= 250 ml.
Exclusion: Previously diagnosed dilatation of the left ventricle, not associated with the development of aortic regurgitation; Pregnancy in the first 12 months after surgery; Acute coronary event diagnosed within 12 months after aortic valve surgery; Indications for resynchronization therapy or permanent right ventricular pacing in the first 12 months after aortic valve surgery; History of myocardial infarction; Indications on simultaneous myocardial revascularisation; Re-do cardiac surgery for any reason within 12 months after aortic valve surgery; Infectious endocarditis; Acute aortic regurgitation of any etiology; Long-term persistent or permanent form of atrial fibrillation; Simultaneous participation in other studies; Presence of implanted pacemakers; Refusal to sign informed consent.