The Influence of Secretin Stimulated Pancreatic Secretion on ctDNA Expression in Patients With Pancreatic Ductal Adenocarcinoma: The Role of Biomarkers in Determining the Prognosis of Pancreatic Ductal Adenocarcinoma
Key facts
- Where
- Prague, CzechiaSee the site
Where in Czechia
- Department of Surgery, Military University Hospital in PraguePrague, CzechiaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Charles University, Czech Republic
- Trial code
- NCT06807112
- Record updated
- 4 February 2025
- Original description
The goal of this study is to assess the influence of pancreatic secretion stimulation by intravenously administered secretin on circulating tumor DNA in patients with pancreatic ductal adenocarcinoma. Additional aim of the study is to analyse a role of specific biomarkers in determining the prognosis of this disease. The main question o answer is:Read full original descriptionShow less
The Influence of Secretin Stimulated Pancreatic Secretion on Circulating Tumor DNA Expression in Patients With Pancreatic Ductal Adenocarcinoma: The Role of Biomarkers in Determining the Prognosis of Pancreatic Ductal Adenocarcinoma
The goal of this study is to assess the influence of pancreatic secretion stimulation by intravenously administered secretin on circulating tumor DNA in patients with pancreatic ductal adenocarcinoma. Additional aim of the study is to analyse a role of specific biomarkers in determining the prognosis of this disease. The main question o answer is:
Does intravenous secretin administration potentiate the release of circulating tumor DNA in patients with pancreatis ductal adenocarcinoma?
Additional question is:
Is there a biomarker specific and sensitive enough to help to predict the prognosis and the at the time status of the disease?
Participants scheduled for surgical treament due to pancreatic ductal adenocarcinoma will be included and stimulated with intravenously administered secretin, their peripheral blood samples will then be analyzed for ctDNA levels.
Inclusion: patients diagnosed with pancreatic ductal adenocarcinoma; patients indicated for surgery by multidisciplinary tumor board; patients without previously administered chemotherapy; patients with previously administered chemotherapy.
Exclusion: patients diagnosed with pancreatic ductal adenocarcinoma, at the time indicated for different than surgical therapy.