NCT06807892Recruiting
Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients
CARE-MH: Comparison of Two Cognitive-Motor Rehabilitation Approaches Via Exergames: a Study of Cognitive, Motor and Behavioral Functions in Huntington's Disease Patients
Source: ClinicalTrials.gov · Last updated 17 Mar 2026
Brief summary (registry, in English)
Huntington's disease (HD) is a rare, hereditary neurodegenerative disorder. It generally manifests itself between the ages of 40 and 50, and results in motor impairment (choreic movements, balance disorders, gait disorders, etc.), cognitive impairment (executive functions, attention, etc.) and behavioral impairment (apathy, depression, irritability, etc.). To date, there is no curative treatment for HD, and drug therapies have little effect on symptomatology, particularly motor symptoms. Physical activity and cognitive stimulation appear to be promising tools in the fight against the progression of various symptoms in certain progressive neurological conditions, including HD. In addition, the use of exergame as an interface is becoming increasingly widespread and offers encouraging prospects in the management of certain neurodegenerative diseases (Parkinson's disease, multiple sclerosis, spinocerebellar ataxia type 3). The aim of our project is to carry out a preliminary evaluation of the clinical benefit of a management program combining physical activity and cognitive stimulation, compared with a sequential management program.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 40 (estimated)
- First submitted
- 23 Jan 2025
- Start date
- 31 Jul 2025
- Primary completion date
- 17 Oct 2027
- Lead sponsor
- University Hospital, Angers
- Diseases
- Huntington's disease
- NCT number
- NCT06807892
What you commit to
- Study type: Interventional
- Planned participants: 40
- From 31 Jul 2025 to the primary completion date, 17 Oct 2027
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other illness
- History likely to interfere with cognition (established stroke, sequelae of traumatic brain injury, active epilepsy, learning disorders, alcohol dependence syndrome, drug use, psychiatric disorders), severe cognitive deficit (MMSE \<16), clinically significant pathological condition which, in the investigator's opinion, could interfere with the subject's safety or the evaluation of study results
- Persons under compulsory psychiatric care
Other
- Poor understanding of the French language
- Participation in interventional research modifying management
- Pregnant or breast-feeding women
- Persons deprived of their liberty by administrative or judicial decision
Who the study is looking for
- Adults at inclusion
- Huntington's disease diagnosed and confirmed by genetic analysis
- Patient with stage 1-2 HD with a motor UHDRS score ≥ 5 and a CFT between 6 \< CFT ≤ 13
- Patient with written informed consent or third-party consent
- Affiliated or beneficiary of a social security scheme
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Angers University Hospital Coordinator of this site? Confirm its status | Angers | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.