Factorial Optimization Trial to Test Cognitive Behavioral Therapy Components for Multiple Sclerosis Fatigue
Key facts
- Where
- Seattle, United StatesSee the site
Where in United States
- Multiple Sclerosis Center at UW Medical Center - NorthwestSeattle, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Washington
- Trial code
- NCT06809192
- Record updated
- 16 March 2026
- Original description
This randomized controlled factorial trial will examine whether and how relaxation training, behavioral activation, and cognitive therapy improve fatigue and functioning in fatigued adults living with multiple sclerosis.Read full original descriptionShow less
Factorial Optimization Randomized Controlled Trial to Test The Effects of Cognitive Behavioral Therapy Components For Multiple Sclerosis Fatigue
This randomized controlled factorial trial will examine whether and how relaxation training, behavioral activation, and cognitive therapy improve fatigue and functioning in fatigued adults living with multiple sclerosis.
Inclusion: Confirmed MS diagnosis of any subtype; Score of 4 or higher on the Fatigue Severity Scale; Able to fluently converse and read in English; 18 years of age or older; Able to comply with study procedures and complete self-report measures; Willing to have intervention sessions audiotaped for fidelity coding; Has experienced fatigue for 3 or more months.
Exclusion: Change in disease modifying medications (DMTs) in the prior three months (although participants will be considered eligible after the 3-month window); MS relapse within last 30 days (although participants will be considered eligible after the 30-day window); Current suicidal ideation with intent or plan as indicated by a score of ≥1 on the Patient Health Questionnaire-9 suicide item and further assessment via the Columbia Suicide Severity Rating Scale (although individuals with suicidal ideation but no intent or plan will be considered eligible); Currently engaged in psychotherapy for fatigue; Currently participating in another research study that could impact fatigue such as intervention studies targeting mood, energy management, exercise/physical activity, and diet (although participants can be screened for eligibility again once they have completed the other research study).