COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
Key facts
- Where
- Toronto, CanadaSee the site
- Phase
- Phase 1/2
Where in Canada
- St. Michael's HospitalToronto, CanadaContact: Amir Khoshbin, MD, FRCS (C)Taking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Unity Health Toronto
- Trial code
- NCT06809998
- Record updated
- 30 July 2026
- Original description
Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA. The secondary outcome was to assess the effect of contralateral corticosteroid injection on pain and functional outcomes of patients undergoing TKA.Read full original descriptionShow less
COSTI: COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty - A Triple Blinded, Randomized Controlled Trial Pilot Study
Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA. The secondary outcome was to assess the effect of contralateral corticosteroid injection on pain and functional outcomes of patients undergoing TKA.
Inclusion: Patients 18 years of age and older; Primary osteoarthritis diagnosis with indication for primary elective unilateral TKA; No previous contralateral knee injections (steroids/biologics) within one year of study; Not scheduled for bilateral TKA or a subsequent staged contralateral TKA within the next six months; No previous or active infection or trauma (osseous/ligamentous/extensor mechanism) on the contralateral knee; Contralateral knee pain \& symptoms - defined as a VAS of >4/10 at initial pre-op visit; Contralateral knee OA quantified as: Kellgren and Lawrence grade >2-4; Assessed by PI (AK) who will not be contributing any patients to the study through examination of blinded knee radiographs (3 views: AP/lateral/Sunrise); Patient is able to read and understand English and provide informed consent to participation in the study.
Exclusion: Previous TKA or ORIF or nailing on either knee; Previous or active knee infection or extensor mechanism disruption; Previous arthroscopy on either knee; Medical contraindication to elective TKA surgery; Cognitive impairment (dementia, Alzheimer's, uncontrolled delirium) which will prevent patients from completing primary outcome measure or comply with follow-up requirements; Other aetiologies of OA that warrants TKA (inflammatory or post traumatic arthritis).