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Sleep Breathing After Stroke and Later Fatigue

Studies whether breathing problems during sleep early after stroke relate to later fatigue.

Key facts

Who runs it
Blekinge County Council Hospital
Where
Karlskrona, SwedenSee the site
Trial code
Registry title
Sleep-Disordered Breathing in the Acute Phase After Stroke and Neuropsychiatric Outcomes
Status
Not yet recruiting
People taking part
340 people, planned
Started
20 Feb 2025
Expected to end
20 Dec 2027
Type of study
Observational
Record updated
6 February 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults in hospital after a stroke, or after a TIA with a matching brain scan finding. It studies breathing during sleep and fatigue after stroke.

Age
Older than 18 years
Sex
All sexes can join
Disease stage
Stroke (ischemic stroke, bleeding inside the brain, or bleeding around the brain), or TIA with a brain MRI lesion that fits the symptoms

Main reasons for not taking part

  • Stroke caused by an injury
  • Bleeding linked to a tumor
  • Expected survival of less than 3 months
  • Unconsciousness (RLS above 3)

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

  • Age >18 years
  • Stroke according to WHO definition (31) (ischemic stroke, intracerebral hemorrhage, or subarachnoid hemorrhage)
  • TIA with MRI-verified lesions corresponding to symptoms
  • Informed consent to participate

Who cannot take part

  • Traumatic stroke
  • Tumor-associated bleeding
  • Expected survival <3 months
  • Unconsciousness (RLS >3)

Where in Sweden

  • Blekinge HospitalKarlskrona, SwedenContact: Joseph Aked, MD, PhDNo longer taking part

About the trial

What the trial wants to find out

In people who have had a stroke or a transient ischemic attack (TIA), it is common to have problems with breathing patterns during sleep, particularly a condition called obstructive sleep apnea. Another common long-term problem after a stroke is post-stroke fatigue, which affects function and quality of life after stroke. There is currently no clearly effective treatment for post-stroke fatigue. We are investigating whether there might be a connection between sleep-related breathing disturbances, and the risk of developing long-term post-stroke fatigue

Read full original descriptionShow less

The project is being conducted at Blekingesjukhuset Karlskrona, and inpatients with stroke are asked to participate. Participants are equipped with a sleep analysis pad under the mattress that measures breathing patterns during the night, as well as a wrist-worn device that measures oxygen saturation in the blood. Participants are also asked about their functional level in daily life and any symptoms of obstructive sleep apnea. One year after the stroke, participants are invited for a follow-up visit where we ask about post-stroke fatigue, depressive symptoms, and treatment and investigations related to the stroke.

We will then investigate the relationship between sleep-related breathing disturbances, measured early after stroke, and the risk of significant fatigue after the stroke. This could lead to future studies with treatment trials for obstructive sleep apnea in certain individuals with post-stroke fatigue. The study could also lead to potentially increased awareness that these conditions might be connected, which could result in a higher likelihood of detecting treatable obstructive sleep apnea in certain subgroups after stroke.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Sleep-Disordered Breathing in the Acute Phase After Stroke and Neuropsychiatric Outcomes
Plain-language title
Sleep Breathing After Stroke and Later FatigueGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
6 February 2025