Short Radiation Course Before Surgery for Retroperitoneal Sarcoma
Tests short-course radiation before surgery in adults with retroperitoneal sarcoma, a tumor in the abdomen.
Plain-language title generated from the registry record
Registry title: Short Course Radiation Treatment for Patients With Primary or Locally Recurrent Retroperitoneal Sarcoma Prior to Surgery
Key facts
- Where
- Boston, United StatesSee the site
- Phase
- Phase 1
Where in United States
- Brigham and Women's Hospital / Dana-Farber Cancer InstituteBoston, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Brigham and Women's Hospital
- Trial code
- NCT06812052
- Record updated
- 14 October 2025
- Original description
To determine the safety of moderately hypofractionated radiation in the treatment of primary and locally recurrent RPS, based on the evaluation of acute radiation-related toxicity profile of each participant (30-day radiation toxicity)Read full original descriptionShow less
Prospective Phase I Trial of Hypofractionated Radiation Therapy in Retroperitoneal Sarcoma
To determine the safety of moderately hypofractionated radiation in the treatment of primary and locally recurrent RPS, based on the evaluation of acute radiation-related toxicity profile of each participant (30-day radiation toxicity)
Inclusion: Participants must have a histologically confirmed STS of the retroperitoneal space or infra-peritoneal spaces of pelvis; Participant must have radiologically measurable disease (RECIST 1.1), as confirmed by abdomino-pelvic CT or MRI; Participant must have primary, locally recurrent, or metastatic disease requiring treatment of the retroperitoneal mass; Tumor must be suitable for radiotherapy and surgery based on pre-treatment CT scan/MRI in multidisciplinary discussion with surgeon and radiation oncologist (anticipated macroscopically complete resection, R0/R1 resection); Age: 18 years or older; ECOG performance status ≤2; Absence of history of bowel obstruction, mesenteric ischemia, or severe chronic inflammatory bowel disease; Normal renal function (calculated creatinine clearance ≥50 mL/min); Normal bone marrow and hepatic function (white blood cell count ≥2·5 × 10⁹ cells per L, platelet count ≥80 × 10⁹ cells per L, and total bilirubin <2 times upper limit of normal); Women of child-bearing potential must have a negative pregnancy test within 3 weeks prior to the first day of study treatment; Patients capable of childbearing/reproductive potential should use adequate contraception; Ability to understand and the willingness to sign a written informed consent document.
Exclusion: Prior RT to the RPS; Prior different invasive malignancy may be eligible per the discretion of the treating investigator and review by the Principal Investigator (PI); Prior chemotherapy or immunotherapy within 6 weeks of start of RT; Prior abdominal or pelvic irradiation for other prior malignancy or other disease; HIV-positive individuals on combination antiretroviral therapy are ineligible because of the potential for increased sensitivity to RT; Sarcoma originating from bone structure, abdominal or gynecological viscera; Any of the following histological subtypes: gastrointestinal stromal tumor, rhabdomyosarcoma, primitive neuroectodermal tumor or other small round blue cell sarcoma, osteosarcoma, chondrosarcoma, aggressive fibromatosis, or sarcomatoid or metastatic carcinoma; Pregnant women are excluded from this study because RT has the potential for teratogenic or abortifacient effects.