Studies where a brain tumor called medulloblastoma starts and how it grows
Observes where medulloblastoma starts and grows during surgery in children.
Plain-language title generated from the registry record
Registry title: Intraoperatively Observed Site of Origin and Growth Pattern of Medulloblastoma
Key facts
- Where
- Vienna, AustriaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for children and adults who are referred for surgery to remove a medulloblastoma at a hospital with expertise in pediatric neuro-oncology. The diagnosis must be confirmed after surgery.
- Age
- Children (under 18 years at diagnosis) and adults (over 18 years at diagnosis).
- Sex
- All sexes can join.
- Disease stage
- Medulloblastoma that needs surgical removal. The diagnosis must be confirmed by tissue and molecular tests.
Main reasons for not taking part
- Severe bleeding in the tumor before surgery with clinical worsening
- A complication during surgery, such as bleeding, that blocks a clear view of the brain structures
- Tissue and molecular tests do not confirm medulloblastoma
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- What type of cancer has the patient been diagnosed with?
Source: NCT06814353, who can take part
Where in Austria
- Department of Neurosurgery, Medical University of ViennaVienna, AustriaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Christian Dorfer
- Trial code
- NCT06814353
- Record updated
- 7 February 2025
- Original description
The goal of this observational study is to provide accurate and systematic data on the site of origin and growth pattern of medulloblastoma from a neurosurgical perspective. By integrating intraoperative, radiological and genetic classification data, this study will contribute to our current understanding of the development, site of origin and growth pattern of medulloblastoma and advance the predictive accuracy of radiogenomics models. Patients with histologically confirmed medulloblastoma who undergo surgical resection at a high-volume center with expertise in pediatric neurosurgery will be included.Read full original descriptionShow less
An International Multicenter Prospective Cohort Study Investigating the Intraoperatively Observed Site of Origin and Growth Pattern of the Molecular Groups of Medulloblastoma
The goal of this observational study is to provide accurate and systematic data on the site of origin and growth pattern of medulloblastoma from a neurosurgical perspective. By integrating intraoperative, radiological and genetic classification data, this study will contribute to our current understanding of the development, site of origin and growth pattern of medulloblastoma and advance the predictive accuracy of radiogenomics models. Patients with histologically confirmed medulloblastoma who undergo surgical resection at a high-volume center with expertise in pediatric neurosurgery will be included.
The main questions it aims to answer are:
* Is there a significant difference between the intraoperatively observed site of origin and the preoperatively or postoperatively radiologically assessed site of origin of medulloblastoma? * How does the intraoperatively observed site of origin align with the site of origin associated with the molecular group based on the developmental cell lineage concept of medulloblastoma? * Does incorporating the intraoperatively observed site of origin as a feature improve the predictive accuracy of radiomic models for molecular group classification?
Participants will:
* Undergo intraoperative assessment of site of origin and growth pattern by an experienced pediatric neurosurgeon. * Have their site of origin and growth pattern evaluated on pre- and postoperative magnetic resonance imaging by an neuroradiologist with expertise in pediatric brain tumors.
Inclusion: Patients who are referred for surgical resection of a medulloblastoma at a hospital with expertise in pediatric neurooncology; Both pediatric patients (aged < 18 years at the time of diagnosis) and adult patients (aged > 18 years at the time of diagnosis).
Exclusion: Patients who are preoperatively admitted with severe tumor hemorrhage accompanied by clinical deterioration are excluded because these patients frequently do not receive magnetic resonance imaging as would be necessary for the present study, and the intraoperative assessment of the STO is limited in accuracy due to decreased visibility caused by the intra- and extratumoral hemorrhage; If an intraoperative complication occurs (e.g. bleeding) which impairs visibility of the neuroanatomic structures and does not allow an accurate assessment of the STO, the patient is excluded; If the histopathological and molecular analysis does not confirm the diagnosis of a MB, the patient has to be excluded as well.