New Tests for Tuberculosis in Children
Studies new ways to test children for lung tuberculosis, using stool, urine and masks.
Plain-language title generated from the registry record
Registry title: Improving the Outcomes of Children With Tuberculosis Through Innovative Diagnostics and Treatment Monitoring
Key facts
- Where
- Bucharest, RomaniaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 0 and 14 years old?
Source: NCT06815588, who can take part
Where in Romania
- Marius Nasta Institute of PneumologyBucharest, RomaniaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Research Center Borstel
- Trial code
- NCT06815588
- Record updated
- 7 February 2025
- Original description
This study aims at identifying and evaluating novel diagnostic methods for children evaluated for respiratory tuberculosis. The investigators will use alternative samples like stool, urine, and masks to diagnose children with respiratory tuberculosis. Once diagnosed, the investigators will use target next generation sequencing to determine if the bacillus is resistant to any of the drugs used for treatment. Additionally, children initiated under TB treatment will be followed-up during treatment to measure blood biomarkers for outcome prediction. Finally, spirometry will be performed longitudinally until 3 months after the end of treatment to assess the lung capacity of children treated for respiratory TB. All children initiated on TB treatment will fill in a quality of life questionnaire.Read full original descriptionShow less
Improving the Outcomes of Children With Tuberculosis Through Innovative Diagnostics and Treatment Monitoring
This study aims at identifying and evaluating novel diagnostic methods for children evaluated for respiratory tuberculosis. The investigators will use alternative samples like stool, urine, and masks to diagnose children with respiratory tuberculosis. Once diagnosed, the investigators will use target next generation sequencing to determine if the bacillus is resistant to any of the drugs used for treatment. Additionally, children initiated under TB treatment will be followed-up during treatment to measure blood biomarkers for outcome prediction. Finally, spirometry will be performed longitudinally until 3 months after the end of treatment to assess the lung capacity of children treated for respiratory TB. All children initiated on TB treatment will fill in a quality of life questionnaire.
Inclusion: Children under 15 years evaluated for respiratory TB; Signature of the informed consent form by the parent/guardian and assent form by the child if applicable.
Exclusion: Refusal to sign informed consent.