Manual Therapy for Ankle Joint Damage in People With Hemophilia A
Tests hands-on manual therapy for ankle joint damage in adults with hemophilia A.
Plain-language title generated from the registry record
Registry title: Manual Therapy in Hemophilic Arthropathy of the Ankle
Key facts
- Where
- Murcia, SpainSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT06816056, who can take part
Where in Spain
- Universidad Católica San AntonioMurcia, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Investigación en Hemofilia y Fisioterapia
- Trial code
- NCT06816056
- Record updated
- 10 February 2025
- Original description
Introduction: Haemophilic ankle arthropathy manifests as functional (deficit in muscle strength, mobility and proprioception), intra-articular degenerative alterations and chronic pain. Manual therapy techniques are characterised by treating the soft tissues with the aim of modifying their density, relieving pain, reducing tissue sensitivity and improving the ranges of mobility. The objective is to evaluate the safety and effectiveness of a manual therapy protocol in patients with haemophilic ankle arthropathy.Read full original descriptionShow less
Safety and Efficacy of Manual Therapy in the Treatment of Haemophilic Arthropathy of the Ankle. A Randomised Multicentre Clinical Trial
Introduction: Haemophilic ankle arthropathy manifests as functional (deficit in muscle strength, mobility and proprioception), intra-articular degenerative alterations and chronic pain. Manual therapy techniques are characterised by treating the soft tissues with the aim of modifying their density, relieving pain, reducing tissue sensitivity and improving the ranges of mobility. The objective is to evaluate the safety and effectiveness of a manual therapy protocol in patients with haemophilic ankle arthropathy.
Methods: Randomised crossover clinical trial. 13 patients with haemophilic ankle arthropathy from different regions of Spain will be recruited and randomised into two study groups (experimental and control). Each session of the experimental group will last 50 minutes, with 1 physiotherapy session per week for a period of 3 weeks. Patients will be evaluated at the beginning of the study, after the intervention and after a follow-up period of 4 weeks. The treatment programme includes 10 techniques that must be administered bilaterally. The study variables are the frequency of ankle haemarthrosis, range of movement, pressure pain threshold, pain intensity, joint status, biomechanical analysis of gait and balance, functionality and kinesiophobia.
Expected results: To evaluate the safety of manual therapy in patients with haemophilia. To observe changes in pain, mobility, joint condition, stability and functionality of the ankle, and kinesiophobia.
Inclusion: Patients diagnosed with haemophilia A and B; With severe haemophilia phenotype (<1% FVIII/FIX); Over 18 years of age; With a medical diagnosis of ankle arthropathy and with clinical assessment using the Hemophilia Joint Health Score; On prophylactic or on-demand treatment with coagulation factor VIII/FIX concentrates.
Exclusion: Patients with neurological or cognitive disorders that prevent them from understanding the questionnaires and physical tests; Failure to sign the informed consent document.