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Imaging muscle energy use in childhood leukemia survivors

Studies muscle energy function and weakness in adults who survived acute lymphoblastic leukemia.

Key facts

Who runs it
St. Jude Children's Research Hospital
Where
Memphis, United StatesSee the site
Trial code
Registry title
Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors
Status
Recruiting
People taking part
60 people, planned
Started
2 Jun 2025
Expected to end
Jan 2028
Type of study
Interventional, 2 groups
Treatments tested
  • Magnetic Resonance Imaging
  • Magnetic Resonance Spectroscopy
  • Physical function assessment
  • Peripheral blood sample
  • Skeletal muscle biopsy
  • Muscle Ultrasound
Record updated
17 September 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adult survivors of childhood acute lymphoblastic leukemia (ALL) and a control group, all with low muscle mass. It studies muscle weakness after cancer treatment.

Age
18 years or older
Sex
All sexes can join.
Disease stage
Survivors of childhood acute lymphoblastic leukemia (ALL). Survivors and controls must have low muscle mass (relative lean mass z-score of -0.5 SD or lower).
Earlier treatment
Survivors cannot have had cranial radiation.

Main reasons for not taking part

  • Implanted medical devices or metal that would interfere with MRI or MRS
  • Pregnancy
  • Taking anticoagulants such as aspirin or apixaban
  • Weight over 300 pounds (136 kg)
  • Allergy to local anesthetic such as lidocaine or bupivacaine

The registry criteria, word for word

Show all 12 criteriaShow less

Who can take part

  • Survivor- or Control-Participant is age 18 years old or older at time of consent and enrolled in SJLIFE
  • Survivor- Participant is childhood ALL survivor
  • Survivor- or Control Participant has low muscle mass as defined by relative lean mass z-score of less than or equal to -0.5 SD (lean mass divided by height in meters squared)
  • Survivor - Participant is able and willing to give informed consent

Who cannot take part

  • Survivor-Participant has history of cranial radiation
  • Survivor- or Control-Participant is allergic to local anesthetic (i.e., lidocaine, bupivacaine)
  • Survivor- or Control-Participant has a current history of peripheral motor neuropathy
  • Survivor- or Control-Participant has implanted medical devices or metal that would interfere with MRI or MRS
  • Female Survivor- or Control-Participant is pregnant
  • Survivor- or Control-Participant is taking anticoagulants (e.g. aspirin, apixaban, coumadin, edoxaban, rivaroxaban)
  • Survivor- or Control-Participant weighs more than 300 pounds
  • Survivor- or Control-Participant cannot lie flat on his/her back for 90 minutes or longer

Where in United States

  • St. Jude Children's Research HospitalMemphis, United StatesContact: Puneet Bagga, PhDTaking people

About the trial

What the trial wants to find out

The participants are being asked to take part in this trial, because the participant is a survivor of childhood cancer or agreed to be part of a volunteer group to understand the relation between cancer and cancer treatment and muscle weakness in survivors of Acute Lymphoblastic Leukemia (ALL). ALL is cancer of the blood and bone marrow.

Read full original descriptionShow less

Primary Objective

• To compare muscle mtOXPHOS activity and satellite cell content among ALL survivors and controls.

Secondary Objective

* To evaluate the association between muscle mtOXPHOS, muscle satellite cell content and physical performance in ALL survivors. * To evaluate the association of muscle morphology and epigenetics with muscle mtOXPHOS in ALL survivors.

The 2 groups in the trial

  • SurvivorsTreatment being tested

    Adult survivor of acute lymphoblastic leukemia (ALL) enrolled in St. Jude Life Cohort (SJLIFE).

    Treatment: Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Physical function assessment, Peripheral blood sample, Skeletal muscle biopsy, and Muscle Ultrasound

  • ControlTreatment being tested

    Control participants are not a close relative of someone who has received treatment for childhood cancer or a similar illness; age/sex-matched healthy volunteers and recruited from SJLIFE Control cohort and may be recruited from new SJLIFE Controls.

    Treatment: Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Physical function assessment, Peripheral blood sample, Skeletal muscle biopsy, and Muscle Ultrasound

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Imaging Skeletal Muscle Mitochondrial OXPHOS Activity In Acute Lymphoblastic Leukemia Survivors
Plain-language title
Imaging muscle energy use in childhood leukemia survivorsGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
17 September 2026