Tests a cuff-based treatment after surgery for ruptured brain aneurysm bleeding
Tests remote ischemic conditioning, using a blood pressure cuff, in adults after aneurysm clipping surgery.
Plain-language title generated from the registry record
Registry title: Safety , Feasibility and Preliminary Efficacy of Remote Ischemic Conditioning in Patients With Aneurysmal Subarachnoid Hemorrhage After Aneurysm Clipping
Key facts
- Where
- Beijing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06819657, who can take part
Where in China
- Beijing Tiantan HospitalBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Beijing Tiantan Hospital
- Trial code
- NCT06819657
- Record updated
- 9 September 2025
- Original description
This study was designed to evaluate the safety and efficacy of remote ischemic conditioning (RIC) in patients with aneurysmal subarachnoid hemorrhage (aSAH) following surgical clipping.Read full original descriptionShow less
Remote Ischemic Conditioning for Safety, Feasibility, and Preliminary Efficacy in Patients With Aneurysmal Subarachnoid Hemorrhage After Aneurysm Clipping: An Open-Label, Evaluator-Blinded Randomized Controlled Trial
This study was designed to evaluate the safety and efficacy of remote ischemic conditioning (RIC) in patients with aneurysmal subarachnoid hemorrhage (aSAH) following surgical clipping.
Aneurysmal subarachnoid hemorrhage is a life-threatening condition that occurs when a cerebral aneurysm ruptures, causing bleeding into the subarachnoid space. Surgical clipping of the aneurysm is a standard procedure used to stop the bleeding and prevent re-rupture, thereby stabilizing the patient's condition.
Remote ischemic conditioning (RIC) is a non-invasive treatment that involves using a blood pressure cuff to induce brief, temporary cycles of ischemia and reperfusion in a limb. Research suggests that this process may confer systemic protective effects, potentially improving recovery from brain injury or surgery. Although RIC has shown potential to improve outcomes in patients with other neurological conditions, its effect on patients with aSAH who undergo surgical clipping remains unclear.
This study will evaluate whether RIC can reduce complications, improve neurological function, and enhance overall recovery in these patients. The findings will help determine whether RIC should be incorporated into the standard treatment regimen for aSAH.
Inclusion: Imaging examination confirmed aneurysmal subarachnoid hemorrhage; Responsible aneurysms received craniotomy clipping within 24 hours; 18≤ age ≤80 years old; Informed consent of the participant or legally authorized representative.
Exclusion: Prior neurological impairment (mRS Score >1) or mental illness may confuse neurological or functional assessment; Simultaneously participate in another research program to study a different experimental therapy; Patients with other types of cerebral hemorrhage; Refractory hypertension (systolic blood pressure 180>mmHg or diastolic blood pressure 110>mmHg); Any condition that the investigator believes may increase the patient's risk; Severe comorbidities with a life expectancy of less than 90 days; RIC contraindications: severe soft tissue injury of lower limbs.