Compares thinking and movement rehabilitation approaches in people with multiple sclerosis
Tests cognitive, motor and combined high-tech rehabilitation in adults with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Isolated Versus Combined Cognitive and Motor High-tech Rehabilitation
Key facts
- Where
- Verona, ItalySee the site
Where in Italy
- Sezione medicina fisica e riabilitativa dipartimento di neuroscienzeVerona, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universita di Verona
- Trial code
- NCT06820125
- Record updated
- 11 February 2025
- Original description
The first aim of this project is to investigate the effects of different high-tech neurorehabilitation interventions (cognitive, motor, and combined cognitive-motor) on both cognitive and motor disability outcomes in people with multiple sclerosis (MS).Read full original descriptionShow less
Isolated Versus Combined Cognitive and Motor High-tech Rehabilitation in Patients with Multiple Sclerosis
The first aim of this project is to investigate the effects of different high-tech neurorehabilitation interventions (cognitive, motor, and combined cognitive-motor) on both cognitive and motor disability outcomes in people with multiple sclerosis (MS).
The second aim is to identify the cognitive and motor profiles of MS patients who benefit the most from either the combined cognitive-motor rehabilitation intervention or the isolated cognitive or motor treatments.
Inclusion: presence of mild (one or two neuropsychological tests below the cut-off score, 5th percentile) or severe (more than two neuropsychological tests below the cut-off score, 5th percentile) cognitive impairment,; mild to moderate walking disability with Expanded Disability Status Scale (EDSS) between 3 and 6,; no relapse or associated steroid use in the past three months,; adequate visual and auditory capacity to operate computer software.
Exclusion: any type of rehabilitation intervention in the month prior to recruitment; pharmacological therapy not well defined and/or changed during the study; lower limb botulinum toxin injections within the previous 12 weeks; presence of other neurological disorders than MS,; major psychiatric disorders,; high levels of anxiety and/or depression (score>20 for Depression scale and up to 14 for Anxiety scale on Italian adaptation of the Depression, Anxiety and Stress Scale (DASS-21),; substance abuse,; presence of paroxysmal vertigo.