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Brain scans of movement-watching circuits in people with cerebral palsy

Uses strong MRI to study brain areas active when watching actions, including cerebral palsy.

Key facts

Who runs it
IRCCS Fondazione Stella Maris
Where
Italy2 sites in 1 countryChoose a country to see its sites
Trial code
Registry title
7T Anatomo-functional Characterization of Structures in the Action Observation Network
Status
Recruiting
People taking part
40 people, planned
Started
2 Dec 2024
Planned end
9 Aug 2025
Type of study
Observational, 2 groups
Treatments tested
  • 7T MR exam
  • clinical assessment
Record updated
13 February 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for people with cerebral palsy from brain injury around birth, and healthy volunteers. Everyone has a 7T MRI brain scan.

Age
11 Years to 40 Years
Sex
All sexes can join.
Disease stage
Patients: brain injury before, around or after birth, shown on an earlier brain MRI. Intellectual development normal or mildly lower, so the person can understand and cooperate. Healthy volunteers: no known neurological or psychiatric illness.

Main reasons for not taking part

  • Reasons you cannot have a 7T MRI scan
  • Neurological or psychiatric conditions that stop you from cooperating during the scan
  • Not able to understand and decide for yourself
  • Pregnancy
  • Not understanding the Italian language

The registry criteria, word for word

Show all 14 criteriaShow less

Who can take part

  • Patients with pre-, peri- or post-natal brain injury, documented by a previous MRI examination of the brain
  • Intellectual development within the norm or within the mild deficit area, to guarantee understanding and cooperation in the 7T fMRI study
  • Understanding of the Italian language
  • Absence of known neurological and psychiatric pathologies
  • Understanding of the Italian language

Who cannot take part

  • Contraindications to performing the 7T fMRI exam
  • Neuropsychiatric comorbidity that precludes collaboration in the 7T fMRI study
  • Lack of capacity to understand and to will
  • Pregnancy; For Healthy Controls
  • Contraindications to performing the 7T fMRI exam
  • Neuropsychiatric comorbidity that precludes collaboration in the 7T fMRI study
  • Lack of capacity to understand and to will
  • Pregnancy

Other criteria

  • For CP patients

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 11 and 40 years old?

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

The goal of this study is to explore the anatomical-functional characteristics of the AON circuit (with particular interest for subcortical areas and the cerebellum), and the cortico-subcortical connectivity of the nodes of the AON circuit, using an ultra-high field (7T), high spatial resolution Magnetic Resonance Imaging protocol.

Read full original descriptionShow less

The main questions it aims to answer are:

* Can we demonstrate the involvement of subcortical areas and cerebellum in the AON circuit in each single-subject? * Can we obtain similar results in a small group of patients with Cerebral Palsy (CP), in order to demonstrate the feasibility of this approach for the study of the mechanisms of AON reorganization, after early brain damage? * Are different patterns of functional activation correlated to different clinical characteristics of CP patients?

Participants will perform a 7 Tesla MRI scan, with a functional and anatomical dedicated protocol and will have a comprehensive clinical assessment before the MRI exam.

The 2 groups in the trial

  • Healthy Controls

    Subject without any known neurological and psychiatric pathologies

    Treatment: 7T MR exam

  • CP patients

    Patients with pre-, peri- or post-natal brain injury, as documented in a previous brain MRI examination

    Treatment: 7T MR exam and clinical assessment

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
More Than Cerebral Cortex: 7T Anatomo-functional Characterization of Cortical, Subcortical, and Cerebellar Structures Involved in THE Network of Action Observation
Plain-language title
Brain scans of movement-watching circuits in people with cerebral palsyGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 14 November 2026.
Fit questions
Built from NCT06826287, who can take part
Record updated
13 February 2025